RIPK2 Antikörper (AA 333-532)

Produktnummer ABIN968828

Der Maus Monoklonal Anti-RIPK2-Antikörper wurde für WB und IF validiert. Er ist geeignet, RIPK2 in Proben von Human, Ratte und Hund zu detektieren. Es sind 2+ Publikationen verfügbar.

Kurzübersicht für RIPK2 Antikörper (AA 333-532) (ABIN968828)

Target: RIPK2 (Receptor-Interacting Serine-threonine Kinase 2 (RIPK2))

Reaktivität: Human, Ratte, Hund

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser RIPK2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Klon: 25-RIG

Produktdetails anti-RIPK2 Antikörper

Bindungsspezifität: AA 333-532

Kreuzreaktivität: Hund, Ratte (Rattus)

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Human RIP2/RICK aa. 333-532

Isotyp: IgG1

Anwendungsinformationen

Kommentare:

Related Products: ABIN968536, ABIN967389

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20° C.

Referenzen für anti-RIPK2 Antikörper (ABIN968828)

Inohara, Koseki, Lin, del Peso, Lucas, Chen, Ogura, Núñez: "An induced proximity model for NF-kappa B activation in the Nod1/RICK and RIP signaling pathways." in: The Journal of biological chemistry, Vol. 275, Issue 36, pp. 27823-31, (2000) (PubMed).

Navas, Baldwin, Stewart: "RIP2 is a Raf1-activated mitogen-activated protein kinase kinase." in: The Journal of biological chemistry, Vol. 274, Issue 47, pp. 33684-90, (1999) (PubMed).

Details zu RIPK2

Target: RIPK2 (Receptor-Interacting Serine-threonine Kinase 2 (RIPK2))

Andere Bezeichnung: RIP2/RICK

Hintergrund: Members of the TNFR family (TNFRs, DRs, Fas, lymphotoxin-beta-receptor, CD40, CD30, and OX-40) regulate a variety of cellular responses, such as cell activation, proliferation, differentiation, NF-kappaB activation, and apoptosis. Signaling through TNFR family members involves several families of receptor-associated proteins. RIP and RIP2 (RICK/Cardiak) are ser/thr kinase adaptor molecules that associate with TNFR complexes. Both RIPs contain homologous N-teriminal ser/thr kinase domains, but RIP contains a C-terminal death domain, while RIP2 contains a C-terminal caspase activation and recruitment domain (CARD) similar to those found in IAPs. Both RIP and RIP2 can activate NF-kappaB and cause cell death. RIP2 is recruited to TNFRs through interactions with TRAF1, TRAF5, and TRAF6, and RIP2 activation of NF-kappaB requires IKKalpha, IKKbeta, and IKKgamma. In addition, RIP2 can be activated through interactions with Ras-activated Raf1, and RIP2 can activate ERK1 and ERK2. Thus, RIP proteins may regulate TNFR signaling through both ser/thr kinase activity and interaction with the apoptotic machinery.

Molekulargewicht: 61 kDa

Pathways: T-Zell Rezeptor Signalweg, Neurotrophin Signalübertragung, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Toll-Like Receptors Cascades