CD38 Antikörper (AA 171-292)

Produktnummer ABIN968373

Dieses Anti-CD38-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von CD38 in WB und IF. Geeignet für Human. Dieses Primary Antibody wurde in 2+ Publikationen zitiert.

Kurzübersicht für CD38 Antikörper (AA 171-292) (ABIN968373)

Target: CD38

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD38 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Klon: 22-CD38

Produktdetails anti-CD38 Antikörper

Bindungsspezifität: AA 171-292

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Human CD38 aa. 171-292

Isotyp: IgG1

Anwendungsinformationen

Kommentare:

Related Products: ABIN967389, ABIN968584

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20°C.

Referenzen für anti-CD38 Antikörper (ABIN968373)

Deaglio, Morra, Mallone, Ausiello, Prager, Garbarino, Dianzani, Stockinger, Malavasi: "Human CD38 (ADP-ribosyl cyclase) is a counter-receptor of CD31, an Ig superfamily member." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 160, Issue 1, pp. 395-402, (1998) (PubMed).

Konopleva, Estrov, Zhao, Andreeff, Mehta: "Ligation of cell surface CD38 protein with agonistic monoclonal antibody induces a cell growth signal in myeloid leukemia cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 161, Issue 9, pp. 4702-8, (1998) (PubMed).

Details zu CD38

Target: CD38

Hintergrund: Lymphocyte trafficking is essential for efficient immune responses in that it allows antigen sensitive lymphocytes to encounter antigen and be recruited to sites of infection. Trafficking involves the passage of lymphocytes across the HEV, a process that is mediated by selectins. CD38 is a single-chain type II transmembrane glycoprotein that is expressed by a variety of immature and activated lymphocytes. It mediates a selectin-like binding to endothelial cells, thus functioning as an adhesion molecule. Human and mouse forms of the protein are highly similar and homologous to the Aplysia californica ADP-ribosyl-cyclase. CD38 catalyzes the synthesis of cyclic ADP-ribose (cADPR), a putative endogenous regulator of calcium release. This is thought to be key to CD38-mediated signal transduction. A possible ligand for CD38 is the Ig superfamily protein CD31. In addition, activation of CD38 with a monoclonal antibody induces leukemic cell proliferation. Thus, CD38 is a cell surface protein that is important for lymphocyte migration and may be involved in the propagation of leukemic cells in AML (acute myelogenous leukemia).

Molekulargewicht: 46 kDa