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CD38 Antikörper Primary Antibody

Reaktivität: Human FACS, IHC (fro), IHC (p), WB Wirt: Maus Monoclonal HIT2 unconjugated
Pubmed (3)
Produktnummer ABIN94083
$382.54
Zzgl. Versandkosten $45.00
0.1 mg
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 5 bis 7 Werktagen
  • Target
    CD38
    Reaktivität
    Human
    • 176
    • 63
    • 20
    • 5
    • 2
    • 1
    • 1
    Wirt
    Maus
    • 120
    • 72
    • 35
    • 7
    • 1
    • 1
    Klonalität
    Monoklonal
    Konjugat
    Dieser CD38 Antikörper ist unkonjugiert
    • 75
    • 19
    • 17
    • 13
    • 12
    • 5
    • 5
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Applikation
    Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
    • 167
    • 57
    • 55
    • 45
    • 36
    • 31
    • 29
    • 28
    • 26
    • 8
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Spezifität
    The antibody HIT2 reacts with CD38 (T10), a 45 kDa type II transmembrane glycoprotein strongly expressed mainly on plasma cells and activated T and B lymphocytes, it is an antigenic marker of lymphoid cells.
    HLDA III, WS Code T 155
    Kreuzreaktivität (Details)
    Human
    Aufreinigung
    Purified by protein-A affinity chromatography
    Reinheit
    > 95 % (by SDS-PAGE)
    Immunogen
    Human thymocytes in foetus
    Klon
    HIT2
    Isotyp
    IgG1
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Do not freeze.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.
  • Všianská, Říhová, Varmužová, Suská, Kryukov, Mikulášová, Kupská, Penka, Pour, Adam, Hájek: "Analysis of B-cell subpopulations in monoclonal gammopathies." in: Clinical lymphoma, myeloma & leukemia, Vol. 15, Issue 4, pp. e61-71, 2015 (PubMed).

    Rozková, Novotná, Pytlík, Hochová, Kozák, Bart?nková, Spísek: "Toll-like receptors on B-CLL cells: expression and functional consequences of their stimulation." in: International journal of cancer. Journal international du cancer, Vol. 126, Issue 5, pp. 1132-43, 2010 (PubMed).

    Kolar, Mehta, Pelayo, Capra: "A novel human B cell subpopulation representing the initial germinal center population to express AID." in: Blood, Vol. 109, Issue 6, pp. 2545-52, 2007 (PubMed).

  • Target
    CD38
    Abstract
    Antibody Abstract
    Synonyme
    T10, Cd38-rs1, cd38, ADPRC 1, cADPr hydrolase 1, CD38 molecule, CD38 antigen, CD38 molecule L homeolog, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, CD38, Cd38, cd38.L
    Hintergrund
    CD38 (NAD+ glycohydrolase) is a type II transmembrane glycoprotein able to induce activation, proliferation and differentiation of mature lymphocytes and mediate apoptosis of myeloid and lymphoid progenitor cells. Another role of CD38 is provided by enzymatic activity of its extracellular part. CD38 acts as NAD+ glycohydrolase converting NAD+ into ADP-ribose, as ADP-ribosyl cyclase producing cADPR and as cADPR hydrolase, thus affecting levels of calcium-mobilizing metabolites. ADPR produced by CD38 serves as an important second messenger of neutrophil and dendritic cell migration.
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