CD51 Antikörper (AA 609-722)

Produktnummer ABIN968314

Dieses Maus Monoklonal-Antikörper erkennt spezifisch CD51 in WB und IF. Er zeigt eine Reaktivität gegenüber Human, Maus, Ratte und Hund und wurde in 3+ Publikationen erwähnt.

Kurzübersicht für CD51 Antikörper (AA 609-722) (ABIN968314)

Target: CD51 (ITGAV) (Integrin alpha V (ITGAV))

Reaktivität: Human, Maus, Ratte, Hund

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD51 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Klon: 21-CD51

Produktdetails anti-CD51 Antikörper

Bindungsspezifität: AA 609-722

Kreuzreaktivität: Ratte (Rattus), Hund, Maus

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Human CD51/VNRalpha aa. 609-722

Isotyp: IgG1 kappa

Anwendungsinformationen

Kommentare:

Related Products: ABIN968545, ABIN967389

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20° C.

Referenzen für anti-CD51 Antikörper (ABIN968314)

Bodary, McLean: "The integrin beta 1 subunit associates with the vitronectin receptor alpha v subunit to form a novel vitronectin receptor in a human embryonic kidney cell line." in: The Journal of biological chemistry, Vol. 265, Issue 11, pp. 5938-41, (1990) (PubMed).

Suzuki, Argraves, Arai, Languino, Pierschbacher, Ruoslahti: "Amino acid sequence of the vitronectin receptor alpha subunit and comparative expression of adhesion receptor mRNAs." in: The Journal of biological chemistry, Vol. 262, Issue 29, pp. 14080-5, (1987) (PubMed).

Suzuki, Argraves, Pytela, Arai, Krusius, Pierschbacher, Ruoslahti: "cDNA and amino acid sequences of the cell adhesion protein receptor recognizing vitronectin reveal a transmembrane domain and homologies with other adhesion protein receptors." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 83, Issue 22, pp. 8614-8, (1986) (PubMed).

Details zu CD51

Target: CD51 (ITGAV) (Integrin alpha V (ITGAV))

Andere Bezeichnung: CD51

Hintergrund: Integrins are a family of proteins that mediate intercellular adhesion or adherence to extracellular matrix proteins. Their roles are essential for embryonic development, tumor metastasis, organ function, and proper immune cell function. Family members are heterodimers that contain a larger alpha subunit that is unique to each individual receptor and a smaller beta subunit that can be shared by several receptors. Based on beta subunit content, integrins are divided into the subfamilies beta1, beta2, and beta3. The beta3 subfamily contains the vitronectin receptor (alphaVbeta3) and the platelet protein gpIIb/IIIa. The alpha chain of the vitronectin receptor (VNRalpha, CD51, integrin alphaV) has been reported to consist of a disulfide-linked large extracellular (125 kDa) subunit and a smaller (25 kDa) membrane-anchored subunit. The large subunit contains multiple sequences with homology to calcium-binding sites in other proteins and an RGD-dependent ligand-binding site, while the small subunit contains a transmembrane domain and a short cytoplasmic domain. VNRalpha has been reported to be noncovalently associated with the VNR beta3-chain (CD61, gpIIIa). The VNR mediates cell adhesion to RGD-containing ligands such as vitronectin, von Willebrand factor, fibrinogen, and thrombospondin. This antibody is routinely tested by western blot analysis.
Synonyms: Integrin alphaV, Vitronectin Receptor alpha, VNRalpha

Molekulargewicht: 125 kDa

Pathways: Cell-Cell Junction Organization, Signaling Events mediated by VEGFR1 and VEGFR2, Growth Factor Binding, Integrin Complex