Fatty Acid Synthase Antikörper (AA 9-202)

Produktnummer ABIN968278

Dieses Maus Monoklonal-Antikörper erkennt spezifisch Fatty Acid Synthase in WB und IF. Er zeigt eine Reaktivität gegenüber Human, Maus, Ratte, Kaninchen und Hund und wurde in 3+ Publikationen erwähnt.

Kurzübersicht für Fatty Acid Synthase Antikörper (AA 9-202) (ABIN968278)

Target: Fatty Acid Synthase (FASN)

Reaktivität: Human, Maus, Ratte, Kaninchen, Hund

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Fatty Acid Synthase Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Klon: 23-Fatty Acid Synthase

Produktdetails anti-Fatty Acid Synthase Antikörper

Bindungsspezifität: AA 9-202

Kreuzreaktivität: Hund, Maus, Kaninchen, Ratte (Rattus)

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Human Fatty Acid Synthase aa. 9-202

Isotyp: IgG1

Anwendungsinformationen

Kommentare:

Related Products: ABIN968587, ABIN967389

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20° C.

Referenzen für anti-Fatty Acid Synthase Antikörper (ABIN968278)

Chirala, Huang, Jayakumar, Sakai, Wakil: "Animal fatty acid synthase: functional mapping and cloning and expression of the domain I constituent activities." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 11, pp. 5588-93, (1997) (PubMed).

Jayakumar, Tai, Huang, al-Feel, Hsu, Abu-Elheiga, Chirala, Wakil: "Human fatty acid synthase: properties and molecular cloning." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 19, pp. 8695-9, (1995) (PubMed).

Smith: "The animal fatty acid synthase: one gene, one polypeptide, seven enzymes." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 8, Issue 15, pp. 1248-59, (1995) (PubMed).

Details zu Fatty Acid Synthase

Target: Fatty Acid Synthase (FASN)

Andere Bezeichnung: Fatty Acid Synthase

Hintergrund: Fatty acid biosynthesis occurs in all living organisms and provides essential components of biological membranes as well as a form of energy storage. Animal fatty acid synthase (FAS) is a multifunctional enzyme that catalyzes the synthesis of long-chain fatty acids via sequential condensation of two-carbon units from malonyl-CoA, an intermediate derived from the carboxylation of Acetyl-CoA. FAS is a homodimer of a multifunctional subunit protein that contains seven distinct activities and a site for the prosthetic group 4'-phosphopantetheine (acyl carrier protein). These domains are oriented from N-terminus to C-terminus as follows: beta-keto-acyl synthase, acetyl and malonyl transacylases, enoyl reductase, ketoacyl reductase, acyl carrier protein, and thioesterase. Although all domains are found on each subunit, they are only active following the homodimerization of subunits in an antiparallel (head-to-tail) orientation. This juxtaposition and cooperation between domains forms two centers for acyl chain assembly. Alternative substrates and chain-terminating mechanisms allow for the production of a variety of fatty acids with different lengths and structures.

Molekulargewicht: 265 kDa

Pathways: AMPK Signaling