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N-Cadherin Antikörper (AA 802-819)

CDH2 Reaktivität: Human, Maus, Ratte, Huhn WB, IF, IP Wirt: Maus Monoclonal 32-N unconjugated
Produktnummer ABIN968250
  • Target Alle N-Cadherin (CDH2) Antikörper anzeigen
    N-Cadherin (CDH2) (Cadherin 2 (CDH2))
    Bindungsspezifität
    • 23
    • 15
    • 14
    • 10
    • 6
    • 6
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 802-819
    Reaktivität
    • 142
    • 97
    • 69
    • 21
    • 16
    • 15
    • 8
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Maus, Ratte, Huhn
    Wirt
    • 88
    • 63
    • 4
    • 4
    • 3
    Maus
    Klonalität
    • 81
    • 81
    Monoklonal
    Konjugat
    • 91
    • 16
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser N-Cadherin Antikörper ist unkonjugiert
    Applikation
    • 124
    • 60
    • 46
    • 43
    • 32
    • 25
    • 18
    • 15
    • 14
    • 13
    • 12
    • 8
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)
    Kreuzreaktivität
    Human, Ratte (Rattus), Huhn
    Produktmerkmale
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Mouse N-Cadherin aa. 802-819
    Klon
    32-N
    Isotyp
    IgG1
    Top Product
    Discover our top product CDH2 Primärantikörper
  • Kommentare

    Related Products: ABIN967389, ABIN968535

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store undiluted at -20°C.
  • Izawa, Nishizawa, Ohtakara, Inagaki: "Densin-180 interacts with delta-catenin/neural plakophilin-related armadillo repeat protein at synapses." in: The Journal of biological chemistry, Vol. 277, Issue 7, pp. 5345-50, (2002) (PubMed).

    Nürnberger, Bacallao, Phillips: "Inversin forms a complex with catenins and N-cadherin in polarized epithelial cells." in: Molecular biology of the cell, Vol. 13, Issue 9, pp. 3096-106, (2002) (PubMed).

    Bhowmick, Ghiassi, Bakin, Aakre, Lundquist, Engel, Arteaga, Moses: "Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism." in: Molecular biology of the cell, Vol. 12, Issue 1, pp. 27-36, (2001) (PubMed).

    Cowin: "Unraveling the cytoplasmic interactions of the cadherin superfamily." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 23, pp. 10759-61, (1994) (PubMed).

    Miyatani, Shimamura, Hatta, Nagafuchi, Nose, Matsunaga, Hatta, Takeichi: "Neural cadherin: role in selective cell-cell adhesion." in: Science (New York, N.Y.), Vol. 245, Issue 4918, pp. 631-5, (1989) (PubMed).

  • Target
    N-Cadherin (CDH2) (Cadherin 2 (CDH2))
    Andere Bezeichnung
    N-Cadherin (CDH2 Produkte)
    Synonyme
    CD325 antikoerper, CDHN antikoerper, CDw325 antikoerper, NCAD antikoerper, N-cadherin antikoerper, cadherin-2 antikoerper, cdhn antikoerper, ncad antikoerper, cdw325 antikoerper, CDH2 antikoerper, Cadherin-2 antikoerper, Ncad antikoerper, glo antikoerper, lyr antikoerper, pac antikoerper, wu:fb47h04 antikoerper, cadherin 2 antikoerper, cadherin 2 S homeolog antikoerper, cadherin 2, type 1, N-cadherin (neuronal) antikoerper, CDH2 antikoerper, cdh2.S antikoerper, cdh2 antikoerper, Cdh2 antikoerper
    Hintergrund
    Cadherins are a family of Ca2+-dependent intercellular adhesion molecules that play a central role in controlling morphogenetic movements during development. Their function is regulated by association with the actin cytoskeleton by a complex of cytoplasmic proteins called the catenins (alpha, beta, gamma). Members of the cadherin family include P-cadherin, E-cadherin (uvomorulin), N-cadherin (neural cadherin), R-cadherin, cadherin 5, L-CAM, and EP-cadherin. N-cadherin mRNA is found at elevated levels in brain and heart and at a much lower level in liver. Mechanisms such as mRNA expression, cytokine modulation, and protease-mediated turnover modulate N-cadherin protein levels during development. In addition, N-cadherin function is indirectly regulated by endogenous kinases and phosphatases. Tyrosine phosphorylation of beta-catenin complexed with N-cadherin results in dissociation of N-cadherin from actin. However, N-cadherin also interacts with a PTP1B-like phosphatase that dephosphorylates beta-catenin and promotes N-cadherin/actin association. Thus, N-cadherin is an integral adhesion molecule whose function is regulated by protein-protein interactions and phosphorylation/dephosphorylation events.
    Molekulargewicht
    130 kDa
    Pathways
    Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Synaptic Membrane
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