HMOX1 Antikörper (AA 150-286)

Produktnummer ABIN968130

Dieses Anti-HMOX1-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von HMOX1 in WB, IHC, IP und IF. Geeignet für Human. Dieses Primary Antibody wurde in 4+ Publikationen zitiert.

Kurzübersicht für HMOX1 Antikörper (AA 150-286) (ABIN968130)

Target: HMOX1 (Heme Oxygenase (Decycling) 1 (HMOX1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser HMOX1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)

Klon: 23-Heme Oxygenase 1

Produktdetails anti-HMOX1 Antikörper

Bindungsspezifität: AA 150-286

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Human Heme Oxygenase 1 (HO-1) aa. 150-286

Isotyp: IgG1

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20°C.

Referenzen für anti-HMOX1 Antikörper (ABIN968130)

Suzuki, Ishizaka, Tsukamoto, Minami, Taguchi, Nagai, Ohno: "Pressurization facilitates adenovirus-mediated gene transfer into vein graft." in: FEBS letters, Vol. 470, Issue 3, pp. 370-4, (2000) (PubMed).

Foresti, Clark, Green, Motterlini: "Thiol compounds interact with nitric oxide in regulating heme oxygenase-1 induction in endothelial cells. Involvement of superoxide and peroxynitrite anions." in: The Journal of biological chemistry, Vol. 272, Issue 29, pp. 18411-7, (1997) (PubMed).

Ishikawa, Navab, Leitinger, Fogelman, Lusis: "Induction of heme oxygenase-1 inhibits the monocyte transmigration induced by mildly oxidized LDL." in: The Journal of clinical investigation, Vol. 100, Issue 5, pp. 1209-16, (1997) (PubMed).

Yoshida, Biro, Cohen, Müller, Shibahara: "Human heme oxygenase cDNA and induction of its mRNA by hemin." in: European journal of biochemistry / FEBS, Vol. 171, Issue 3, pp. 457-61, (1988) (PubMed).

Details zu HMOX1

Target: HMOX1 (Heme Oxygenase (Decycling) 1 (HMOX1))

Andere Bezeichnung: Heme Oxygenase 1

Hintergrund: Heme oxygenases 1 and 2 (HO-1, HO-2) cleave the heme molecule, resulting in the production of carbon monoxide (CO) and biliverdin. HO-1 is a 288 amino acid monooxygenase with a molecular weight of 32 kDa. While HO-2 is constitutively expressed in tissues, HO-1 is rapidly induced by several stimuli such as lutathione depletion, hemin, heat shock, heavy metals, oxidative stress, oxidized LDL, anoxia, and endotoxic shock. Similar to nitric oxide (NO), CO activates guanylate cyclase and reduces platelet aggregation. Several conditions that increase NO also induce HO-1 expression and activity. This suggests that NO synthases, Cox-2, and HO-1 are part of a general defense mechanism against stress and pathogen invasion.

Molekulargewicht: 32 kDa

Pathways: Transition Metal Ion Homeostasis, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, SARS-CoV-2 Protein Interaktom