ITGB1 Antikörper (AA 76-256)

Produktnummer ABIN967991

Produktdetails anti-ITGB1 Antikörper

Target: ITGB1 (Integrin beta 1 (ITGB1))

Bindungsspezifität: AA 76-256

Reaktivität: Human, Maus, Ratte, Hund, Huhn

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ITGB1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Kreuzreaktivität: Hund, Ratte (Rattus), Maus, Huhn

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Human CD29 aa. 76-256

Klon: 18-CD29

Isotyp: IgG1

Anwendungsinformationen

Kommentare:

Related Products: ABIN968533, ABIN967389

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20° C.

Referenzen für anti-ITGB1 Antikörper (ABIN967991)

Ivaska, Whelan, Watson, Parker: "PKC epsilon controls the traffic of beta1 integrins in motile cells." in: The EMBO journal, Vol. 21, Issue 14, pp. 3608-19, (2002) (PubMed).

Tang, Hao, Fitzgerald, Sasaki, Landon, Inagami: "Pyk2/CAKbeta tyrosine kinase activity-mediated angiogenesis of pulmonary vascular endothelial cells." in: The Journal of biological chemistry, Vol. 277, Issue 7, pp. 5441-7, (2002) (PubMed).

Huan, van Adelsberg: "Polycystin-1, the PKD1 gene product, is in a complex containing E-cadherin and the catenins." in: The Journal of clinical investigation, Vol. 104, Issue 10, pp. 1459-68, (1999) (PubMed).

Yeh, Peng, Huang: "Accutin, a new disintegrin, inhibits angiogenesis in vitro and in vivo by acting as integrin alphavbeta3 antagonist and inducing apoptosis." in: Blood, Vol. 92, Issue 9, pp. 3268-76, (1998) (PubMed).

Cervella, Silengo, Pastore, Altruda: "Human beta 1-integrin gene expression is regulated by two promoter regions." in: The Journal of biological chemistry, Vol. 268, Issue 7, pp. 5148-55, (1993) (PubMed).

Details zu ITGB1

Target: ITGB1 (Integrin beta 1 (ITGB1))

Andere Bezeichnung: CD29 (ITGB1 Produkte)

Synonyme: CD29 antikoerper, FNRB antikoerper, GPIIA antikoerper, MDF2 antikoerper, MSK12 antikoerper, VLA-BETA antikoerper, VLAB antikoerper, 4633401G24Rik antikoerper, AA409975 antikoerper, AA960159 antikoerper, ENSMUSG00000051907 antikoerper, Fnrb antikoerper, Gm9863 antikoerper, gpIIa antikoerper, cd29 antikoerper, fnrb antikoerper, gpiia antikoerper, itgb1 antikoerper, mdf2 antikoerper, msk12 antikoerper, vla-beta antikoerper, vlab antikoerper, itgb1-a antikoerper, itgb1-b antikoerper, integrin subunit beta 1 antikoerper, integrin beta 1 (fibronectin receptor beta) antikoerper, integrin subunit beta 1 S homeolog antikoerper, integrin beta 1 antikoerper, integrin subunit beta 1 L homeolog antikoerper, ITGB1 antikoerper, Itgb1 antikoerper, itgb1.S antikoerper, LOC100009173 antikoerper, itgb1.L antikoerper

Hintergrund: Integrins are membrane receptors that mediate cell-cell or cell-matrix adhesion. All integrins are transmembrane heterodimers composed of alpha and beta subunits and are connected to the cytoskeleton. At least 20 integrins, formed from combinations of 12 alpha and 9 beta subunits, have been reported. Many of these have been implicated as transducers of molecular signals. The beta1 subgroup of this receptor family comprises at least six different dimer combinations. Among these combinations, alpha2beta1 is associated with type I collagen and laminin binding and regulation, alpha3beta1 is a receptor for laminin and epiligrin, and alpha5beta1 is a fibronectin receptor. beta1 integrins play an important role in several aspects of epidermal differentiation and morphogenesis. Expression of the beta1 subunit is regulated by growth factors such as TGF-beta1. Integrin activation, which enhances binding of T cells to endothelium, is regulated in part by phosphatidylinositol 3-kinase. Focal adhesion kinase (FAK) and paxillin have been reported to independently bind the C-terminal, cytoplasmic domain of the beta1 subunit. FAK is reported to be enzymatically activated upon engagement of integrins with their ligands and paxillin is phosphorylated on tyrosine upon activation of FAK. This antibody is routinely tested by western blot analysis.
Synonyms: Integrin beta1, platelet GPIIa, VLA beta-chain

Molekulargewicht: 130 kDa

Pathways: Cell-Cell Junction Organization, Regulation of G-Protein Coupled Receptor Protein Signaling, CXCR4-mediated Signaling Events, Signaling of Hepatocyte Growth Factor Receptor, Integrin Complex, SARS-CoV-2 Protein Interaktom