HSP90 Antikörper (AA 586-732)

Produktnummer ABIN967958

Produktdetails anti-HSP90 Antikörper

Target: HSP90 (Heat Shock Protein 90 (HSP90))

Bindungsspezifität: AA 586-732

Reaktivität: Human, Ratte, Maus, Huhn, Hund

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser HSP90 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC), Immunofluorescence (IF)

Kreuzreaktivität: Maus, Ratte (Rattus), Hund, Huhn

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Human Hsp90 aa. 586-732

Klon: 68-Hsp90

Isotyp: IgG1

Anwendungsinformationen

Kommentare:

Related Products: ABIN968535, ABIN967389

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20°C.

Referenzen für anti-HSP90 Antikörper (ABIN967958)

Murata, Suzuki, Yamawaki, Sato, Hori, Karaki, Ozaki: "Dexamethasone prevents impairment of endothelium-dependent relaxation in arteries cultured with fetal bovine serum." in: European journal of pharmacology, Vol. 515, Issue 1-3, pp. 134-41, (2005) (PubMed).

Miyamoto, Nakayama, Imaki, Hirose, Jiang, Abe, Tsukiyama, Nagahama, Ohno, Hatakeyama, Nakayama: "Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cdelta." in: Nature, Vol. 416, Issue 6883, pp. 865-9, (2002) (PubMed).

Murata, Sato, Hori, Ozaki, Karaki: "Decreased endothelial nitric-oxide synthase (eNOS) activity resulting from abnormal interaction between eNOS and its regulatory proteins in hypoxia-induced pulmonary hypertension." in: The Journal of biological chemistry, Vol. 277, Issue 46, pp. 44085-92, (2002) (PubMed).

Brouet, Sonveaux, Dessy, Balligand, Feron: "Hsp90 ensures the transition from the early Ca2+-dependent to the late phosphorylation-dependent activation of the endothelial nitric-oxide synthase in vascular endothelial growth factor-exposed endothelial cells." in: The Journal of biological chemistry, Vol. 276, Issue 35, pp. 32663-9, (2001) (PubMed).

Pritchard, Ackerman, Gross, Stepp, Shi, Fontana, Baker, Sessa: "Heat shock protein 90 mediates the balance of nitric oxide and superoxide anion from endothelial nitric-oxide synthase." in: The Journal of biological chemistry, Vol. 276, Issue 21, pp. 17621-4, (2001) (PubMed).

Rebbe, Ware, Bertina, Modrich, Stafford: "Nucleotide sequence of a cDNA for a member of the human 90-kDa heat-shock protein family." in: Gene, Vol. 53, Issue 2-3, pp. 235-45, (1987) (PubMed).

Details zu HSP90

Target: HSP90 (Heat Shock Protein 90 (HSP90))

Andere Bezeichnung: Hsp90 (HSP90 Produkte)

Hintergrund: The 90 kDa heat shock protein (Hsp90), a highly conserved stress-induced protein, is abundantly expressed in most tissues under nonstress conditions and is required for eukaryotic cell viability. Hsp90 interacts with a number of signaling molecules, other heat shock proteins, and cytoskeletal proteins. However, the function of Hsp90 in these complexes remains unclear. It is thought that Hsp90 plays a common role in a number of diverse signaling systems due to its physical association with v-Src family tyrosine kinases, steroid hormone receptors, the Raf serine/threonine kinase, the basic-helix-loop-helix dioxin receptor, and the betagamma subunits of G proteins.
Synonyms: Heat Shock Protein-90

Molekulargewicht: 90 kDa

Pathways: M Phase, Regulation of Cell Size, Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals