Flotillin 2 Antikörper (AA 122-379)

Produktnummer ABIN967933

Produktdetails anti-Flotillin 2 Antikörper

Target: Flotillin 2 (FLOT2)

Bindungsspezifität: AA 122-379

Reaktivität: Human, Ratte, Maus, Hund, Huhn

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Flotillin 2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Kreuzreaktivität: Hund, Ratte (Rattus), Maus, Huhn

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Please refer to us for technical protocols.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Human ESA aa. 122-379

Klon: 29-Flotillin

Isotyp: IgG1

Anwendungsinformationen

Kommentare:

Related Products: ABIN968536, ABIN967389

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20°C.

Referenzen für anti-Flotillin 2 Antikörper (ABIN967933)

Nebl, Pestonjamasp, Leszyk, Crowley, Oh, Luna: "Proteomic analysis of a detergent-resistant membrane skeleton from neutrophil plasma membranes." in: The Journal of biological chemistry, Vol. 277, Issue 45, pp. 43399-409, (2002) (PubMed).

Salzer, Hinterdorfer, Hunger, Borken, Prohaska: "Ca(++)-dependent vesicle release from erythrocytes involves stomatin-specific lipid rafts, synexin (annexin VII), and sorcin." in: Blood, Vol. 99, Issue 7, pp. 2569-77, (2002) (PubMed).

Rybin, Xu, Lisanti, Steinberg: "Differential targeting of beta -adrenergic receptor subtypes and adenylyl cyclase to cardiomyocyte caveolae. A mechanism to functionally regulate the cAMP signaling pathway." in: The Journal of biological chemistry, Vol. 275, Issue 52, pp. 41447-57, (2001) (PubMed).

Stuermer, Lang, Kirsch, Wiechers, Deininger, Plattner: "Glycosylphosphatidyl inositol-anchored proteins and fyn kinase assemble in noncaveolar plasma membrane microdomains defined by reggie-1 and -2." in: Molecular biology of the cell, Vol. 12, Issue 10, pp. 3031-45, (2001) (PubMed).

Schroeder, Stewart-Galetka, Mandavilli, Parry, Goldsmith, Duvic: "Cloning and characterization of a novel epidermal cell surface antigen (ESA)." in: The Journal of biological chemistry, Vol. 269, Issue 31, pp. 19983-91, (1994) (PubMed).

Details zu Flotillin 2

Target: Flotillin 2 (FLOT2)

Andere Bezeichnung: Flotillin-2 (FLOT2 Produkte)

Synonyme: ECS-1 antikoerper, ECS1 antikoerper, ESA antikoerper, ESA1 antikoerper, M17S1 antikoerper, AI573412 antikoerper, Esa antikoerper, reggie-2 antikoerper, CG11547 antikoerper, CG14409 antikoerper, CG32593 antikoerper, DmFlo2 antikoerper, Dmel\\CG32593 antikoerper, FLO2 antikoerper, FLO[Dm]-2 antikoerper, Flo2 antikoerper, flo2 antikoerper, reggie-1 antikoerper, ecs-1 antikoerper, ecs1 antikoerper, esa antikoerper, esa1 antikoerper, flotillin-2 antikoerper, FLOT2 antikoerper, fb48a04 antikoerper, im:7143869 antikoerper, wu:fb48a04 antikoerper, zgc:55821 antikoerper, flotillin 2 antikoerper, Flotillin 2 antikoerper, flotillin 2 L homeolog antikoerper, flotillin 2a antikoerper, FLOT2 antikoerper, Flot2 antikoerper, Flo2 antikoerper, flot2.L antikoerper, flot2 antikoerper, flot2a antikoerper

Hintergrund: Flotillin-2/ESA (epidermal surface antigen) plays a role in intercellular epidermal adhesion. Epidermal surface proteins have an important role in normal epidermal maintenance and function. In addition, they are involved in various autoimmune diseases in which auto-antibodies bind to normal epidermal cell surface proteins. This binding causes cell disadherence that leads to blister formation. Such antibodies have been utilized to identify new proteins involved in epidermal cell adhesion. One of these antibodies, ECS-1, was used to isolate Flotillin-2/ESA. The single copy ESA gene is located on the long arm of human chromosome 17, in the region containing the gene for neurofibromatosis 1 (NF1). ESA mRNA is expressed in cultured keratinocytes, melanocytes, fibroblasts, and carcinoma and melanoma cell lines. Flotillin-2/ESA may play a critical role in epidermal structure and maintenance.
Synonyms: ESA

Molekulargewicht: 42 kDa