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STXBP1 Antikörper (AA 18-1)

Dieses Anti-STXBP1-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von STXBP1 in WB, IHC, IF und IP. Geeignet für Human, Maus und Ratte. Dieses Primary Antibody wurde in 6+ Publikationen zitiert.
Produktnummer ABIN967911

Kurzübersicht für STXBP1 Antikörper (AA 18-1) (ABIN967911)

Target

Alle STXBP1 Antikörper anzeigen
STXBP1 (Syntaxin Binding Protein 1 (STXBP1))

Reaktivität

  • 53
  • 43
  • 34
  • 7
  • 5
  • 5
  • 5
  • 5
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
Human, Maus, Ratte

Wirt

  • 62
  • 6
  • 2
Maus

Klonalität

  • 62
  • 8
Monoklonal

Konjugat

  • 43
  • 4
  • 3
  • 3
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser STXBP1 Antikörper ist unkonjugiert

Applikation

  • 54
  • 29
  • 17
  • 13
  • 13
  • 13
  • 7
  • 7
  • 5
  • 2
  • 2
  • 1
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Klon

31-Munc
  • Bindungsspezifität

    • 15
    • 7
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 18-1

    Kreuzreaktivität

    Maus, Human

    Produktmerkmale

    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

    Aufreinigung

    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

    Immunogen

    Rat Munc-18-1 aa. 381-567

    Isotyp

    IgG1
  • Kommentare

    Related Products: ABIN968545, ABIN967389

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    250 μg/mL

    Buffer

    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store undiluted at -20°C.
  • Curtis, Doneske, Liu, Thaller, McNew, Janz: "Syntaxin 3b is a t-SNARE specific for ribbon synapses of the retina." in: The Journal of comparative neurology, Vol. 510, Issue 5, pp. 550-9, (2008) (PubMed).

    Torii, Zhao, Yi, Takeuchi, Izumi: "Granuphilin modulates the exocytosis of secretory granules through interaction with syntaxin 1a." in: Molecular and cellular biology, Vol. 22, Issue 15, pp. 5518-26, (2002) (PubMed).

    Fisher, Pevsner, Burgoyne: "Control of fusion pore dynamics during exocytosis by Munc18." in: Science (New York, N.Y.), Vol. 291, Issue 5505, pp. 875-8, (2001) (PubMed).

    Zhang, Efanov, Yang, Fried, Kolare, Brown, Zaitsev, Berggren, Meister: "Munc-18 associates with syntaxin and serves as a negative regulator of exocytosis in the pancreatic beta -cell." in: The Journal of biological chemistry, Vol. 275, Issue 52, pp. 41521-7, (2001) (PubMed).

    Shuang, Zhang, Fletcher, Groblewski, Pevsner, Stuenkel: "Regulation of Munc-18/syntaxin 1A interaction by cyclin-dependent kinase 5 in nerve endings." in: The Journal of biological chemistry, Vol. 273, Issue 9, pp. 4957-66, (1998) (PubMed).

    Hata, Slaughter, Südhof: "Synaptic vesicle fusion complex contains unc-18 homologue bound to syntaxin." in: Nature, Vol. 366, Issue 6453, pp. 347-51, (1993) (PubMed).

  • Target

    STXBP1 (Syntaxin Binding Protein 1 (STXBP1))

    Andere Bezeichnung

    Munc-18

    Hintergrund

    There are two Munc-18 isoforms: Munc-18-1 and Munc-18-2. Munc-18-1 (n-sec1 or rb-sec1, 68 kDa) is a neuronal protein that binds tightly to syntaxin 1 and functions in synaptic vesicle exocytosis. Munc-18-2 exhibits 63% amino acid sequence identity with Munc-18-1. Although Munc-18-2 is expressed in most tissues, Munc-18-1 is primarily expressed in brain. Both forms of Munc-18 bind tightly to syntaxins 1A, 2, and 3, but not to syntaxin 4. Syntaxin 1A is a plasma membrane protein implicated in synaptic vesicle docking. Following calcium entry into the presynaptic nerve terminal, the neurotransmitter-containing synaptic vesicle fuses with the plasma membrane at a region known as the active zone. Thus, by virtue of its interaction with syntaxin 1A, Munc-18-1 is thought to have an essential function in neurotransmitter release.

    Molekulargewicht

    68 kDa

    Pathways

    Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport
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