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AKAP5 Antikörper (AA 180-427)

AKAP5 Reaktivität: Human WB, IHC, IF, IP Wirt: Maus Monoclonal 22-AKAP79 unconjugated
Produktnummer ABIN967900
  • Target Alle AKAP5 Antikörper anzeigen
    AKAP5 (A Kinase (PRKA) Anchor Protein 5 (AKAP5))
    Bindungsspezifität
    • 15
    • 7
    • 6
    • 6
    • 6
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 180-427
    Reaktivität
    • 34
    • 20
    • 7
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Wirt
    • 49
    • 1
    Maus
    Klonalität
    • 48
    • 1
    Monoklonal
    Konjugat
    • 19
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser AKAP5 Antikörper ist unkonjugiert
    Applikation
    • 40
    • 22
    • 13
    • 13
    • 6
    • 4
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)
    Produktmerkmale
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Human AKAP79 aa. 180-427
    Klon
    22-AKAP79
    Isotyp
    IgG1
  • Kommentare

    Related Products: ABIN968552, ABIN967389

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store undiluted at -20°C.
  • Schillace, Andrews, Liberty, Davey, Carr: "Identification and characterization of myeloid translocation gene 16b as a novel a kinase anchoring protein in T lymphocytes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 168, Issue 4, pp. 1590-9, (2002) (PubMed).

    Jicha, Weaver, Lane, Vianna, Kress, Rockwood, Davies: "cAMP-dependent protein kinase phosphorylations on tau in Alzheimer's disease." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 19, Issue 17, pp. 7486-94, (1999) (PubMed).

    Coghlan, Perrino, Howard, Langeberg, Hicks, Gallatin, Scott: "Association of protein kinase A and protein phosphatase 2B with a common anchoring protein." in: Science (New York, N.Y.), Vol. 267, Issue 5194, pp. 108-11, (1995) (PubMed).

    Carr, Stofko-Hahn, Fraser, Cone, Scott: "Localization of the cAMP-dependent protein kinase to the postsynaptic densities by A-kinase anchoring proteins. Characterization of AKAP 79." in: The Journal of biological chemistry, Vol. 267, Issue 24, pp. 16816-23, (1992) (PubMed).

  • Target
    AKAP5 (A Kinase (PRKA) Anchor Protein 5 (AKAP5))
    Andere Bezeichnung
    AKAP79 (AKAP5 Produkte)
    Synonyme
    AKAP5 antikoerper, AKAP75 antikoerper, AKAP79 antikoerper, H21 antikoerper, AKAP antikoerper, P75 antikoerper, 3526401B18Rik antikoerper, AKAP 150 antikoerper, AKAP-5 antikoerper, AKAP150 antikoerper, BB098886 antikoerper, Gm258 antikoerper, P150 antikoerper, Akap79 antikoerper, A kinase (PRKA) anchor protein 5 antikoerper, A-kinase anchoring protein 5 antikoerper, AKAP5 antikoerper, Akap5 antikoerper
    Substanzklasse
    Viral Protein
    Hintergrund
    The type II cAMP-dependent Protein Kinase (PKA) is compartmentalized within the cell. To maintain this localization of type II PKAs, the regulatory subunit (RII) interacts with specific RII-anchoring proteins. For instance, attachment of type II PKA to the cytoskeleton occurs through the binding of RII to microtubule-associated protein 2 (MAP2). In brain, several proteins have been identified as PKA type II anchoring proteins and form a family named AKAP (A-Kinase Anchor Proteins). AKAP79 is a 79kDa human RII-anchoring protein. AKAP, PKA type II, and calcineurin (PP2B) can form a tertiary complex, suggesting that both PKA and calcineurin are targeted by a common protein to subcellular sites where they regulate the phosphorylation status of key substrates.
    Molekulargewicht
    79 kDa
    Pathways
    cAMP Metabolic Process
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