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CTNNA1 Antikörper (AA 729-906)

CTNNA1 Reaktivität: Human, Maus, Ratte, Hund, Huhn WB, IF, IP Wirt: Maus Monoclonal 5-a unconjugated
Produktnummer ABIN967813
  • Target Alle CTNNA1 Antikörper anzeigen
    CTNNA1 (Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1))
    Bindungsspezifität
    • 12
    • 7
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 729-906
    Reaktivität
    • 82
    • 49
    • 33
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    Human, Maus, Ratte, Hund, Huhn
    Wirt
    • 65
    • 17
    • 1
    Maus
    Klonalität
    • 55
    • 28
    Monoklonal
    Konjugat
    • 48
    • 6
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CTNNA1 Antikörper ist unkonjugiert
    Applikation
    • 47
    • 30
    • 21
    • 18
    • 17
    • 14
    • 12
    • 7
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)
    Kreuzreaktivität
    Human, Huhn, Hund, Ratte (Rattus)
    Produktmerkmale
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Mouse alpha-Catenin aa. 729-906
    Klon
    5-a
    Isotyp
    IgG1
    Top Product
    Discover our top product CTNNA1 Primärantikörper
  • Kommentare

    Related Products: ABIN968536, ABIN967389

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store undiluted at -20° C.
  • Baki, Marambaud, Efthimiopoulos, Georgakopoulos, Wen, Cui, Shioi, Koo, Ozawa, Friedrich, Robakis: "Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and regulates stability and function of the cadherin/catenin adhesion complex." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 5, pp. 2381-6, (2001) (PubMed).

    Giannini, Vivanco, Kypta: "alpha-catenin inhibits beta-catenin signaling by preventing formation of a beta-catenin*T-cell factor*DNA complex." in: The Journal of biological chemistry, Vol. 275, Issue 29, pp. 21883-8, (2000) (PubMed).

    Huan, van Adelsberg: "Polycystin-1, the PKD1 gene product, is in a complex containing E-cadherin and the catenins." in: The Journal of clinical investigation, Vol. 104, Issue 10, pp. 1459-68, (1999) (PubMed).

    Hirano, Kimoto, Shimoyama, Hirohashi, Takeichi: "Identification of a neural alpha-catenin as a key regulator of cadherin function and multicellular organization." in: Cell, Vol. 70, Issue 2, pp. 293-301, (1992) (PubMed).

    Herrenknecht, Ozawa, Eckerskorn, Lottspeich, Lenter, Kemler: "The uvomorulin-anchorage protein alpha catenin is a vinculin homologue." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 88, Issue 20, pp. 9156-60, (1991) (PubMed).

  • Target
    CTNNA1 (Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1))
    Andere Bezeichnung
    alpha-Catenin (CTNNA1 Produkte)
    Synonyme
    CAP102 antikoerper, 2010010M04Rik antikoerper, AA517462 antikoerper, AI988031 antikoerper, Catna1 antikoerper, CG17947 antikoerper, CT39986 antikoerper, Dalpha-Cat antikoerper, Dalpha-cat antikoerper, DalphaC antikoerper, Dalphacat antikoerper, Dmcatp antikoerper, Dmel\\CG17947 antikoerper, a-Cat antikoerper, a-cat antikoerper, alpha-CAT antikoerper, alpha-cat antikoerper, alpha-catenin antikoerper, alpha-ctn antikoerper, alphaCAT antikoerper, alphaCat antikoerper, alphacat antikoerper, Alpha-Cat antikoerper, dgri_GLEANR_3829 antikoerper, DgriGH19548 antikoerper, GH19548 antikoerper, ctnna antikoerper, cap102 antikoerper, catna1 antikoerper, ctnna1 antikoerper, catenin alpha 1 antikoerper, catenin (cadherin associated protein), alpha 1 antikoerper, alpha Catenin antikoerper, catenin alpha-1 antikoerper, catenin (cadherin-associated protein), alpha 1 antikoerper, catenin alpha 1 S homeolog antikoerper, CTNNA1 antikoerper, Ctnna1 antikoerper, alpha-Cat antikoerper, Dgri\alpha-Cat antikoerper, Tsp_10127 antikoerper, ctnna1 antikoerper, ctnna1.S antikoerper
    Hintergrund
    The catenins (alpha-, beta-, and gamma-) are cytoplasmic proteins that bind to the highly conserved cytoplasmic tail of E-Cadherin. The cadherins, transmembrane adhesion molecules, are found with catenins at adherens junctions (zonula adherens). These junctions are critical for cell-cell adhesion, signal transmission between neighboring cells, and for the anchoring of the actin cytoskeleton. alpha-Catenin (CAP102) shows homology to vinculin, while beta-Catenin is similar to plakoglobin or the Drosophila armadillo gene product. alpha-Catenin was identified as an E-Cadherin-associated protein, however, it also appears to interact with other cadherin family members. There are at least two subtypes of alpha-Catenin: alphaE-Catenin and alphaN-Catenin. The predominant form is known as alphaE-Catenin. It is ubiquitously expressed, but at low levels in the nervous system. The expression of alphaN-Catenin is more restricted and this form predominates in the brain. Increased tyrosine phosphorylation of adherens junction proteins can disrupt catenin-cadherin complexes, leading to changes in cell adhesion properties. It has been noted that down-regulation of this group of proteins often precedes metastasis. In fact, data suggests a correlation between deletions within the alpha-Catenin gene and the development of prostate cancer. This antibody is routinely tested by western blot analysis.
    Molekulargewicht
    102 kDa
    Pathways
    Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Maintenance of Protein Location
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