Annexin A2 Antikörper (AA 1-97)

Produktnummer ABIN967723

Dieser Maus Monoklonal Antikörper detektiert spezifisch Annexin A2 in WB, IHC, IF und IP. Es zeigt Reaktivität gegenüber Proben von Human, Maus, Ratte, Hund und Huhn. Es wurde in 5+ Publikationen zitiert.

Kurzübersicht für Annexin A2 Antikörper (AA 1-97) (ABIN967723)

Target: Annexin A2 (ANXA2)

Reaktivität: Human, Maus, Ratte, Hund, Huhn

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Annexin A2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Klon: 148-Annexin II Light Chain

Produktdetails anti-Annexin A2 Antikörper

Bindungsspezifität: AA 1-97

Kreuzreaktivität: Hund, Huhn, Human

Keine Kreuzreaktivität: Ratte (Rattus), Maus

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Cow Annexin II Light Chain aa. 1-97

Isotyp: IgG1

Anwendungsinformationen

Kommentare:

Related Products: ABIN967389, ABIN968536

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20°C.

Referenzen für anti-Annexin A2 Antikörper (ABIN967723)

Huang, Pawliczak, Cowan, Gladwin, Madara, Logun, Shelhamer: "Epidermal growth factor induces p11 gene and protein expression and down-regulates calcium ionophore-induced arachidonic acid release in human epithelial cells." in: The Journal of biological chemistry, Vol. 277, Issue 41, pp. 38431-40, (2002) (PubMed).

Kwon, Caplan, Filipenko, Choi, Fitzpatrick, Zhang, Waisman: "Identification of annexin II heterotetramer as a plasmin reductase." in: The Journal of biological chemistry, Vol. 277, Issue 13, pp. 10903-11, (2002) (PubMed).

Choi, Fitzpatrick, Filipenko, Fogg, Kassam, Magliocco, Waisman: "Regulation of plasmin-dependent fibrin clot lysis by annexin II heterotetramer." in: The Journal of biological chemistry, Vol. 276, Issue 27, pp. 25212-21, (2001) (PubMed).

Harder, Kellner, Parton, Gruenberg: "Specific release of membrane-bound annexin II and cortical cytoskeletal elements by sequestration of membrane cholesterol." in: Molecular biology of the cell, Vol. 8, Issue 3, pp. 533-45, (1997) (PubMed).

Regnouf, Sagot, Delouche, Devilliers, Cartaud, Henry, Pradel: ""In vitro" phosphorylation of annexin 2 heterotetramer by protein kinase C. Comparative properties of the unphosphorylated and phosphorylated annexin 2 on the aggregation and fusion of chromaffin granule membranes." in: The Journal of biological chemistry, Vol. 270, Issue 45, pp. 27143-50, (1995) (PubMed).

Details zu Annexin A2

Target: Annexin A2 (ANXA2)

Andere Bezeichnung: Annexin II

Hintergrund: Annexin II often exists as a heterotetramer complexed with an 11kDa light chain. This p11 subunit is related to the S100 family of calcium-binding proteins but mutations have rendered it unable to bind calcium. The p11 protein binds to the amino terminus of the annexin II monomer, but not to other annexins. It may regulate the function of annexin II, as the tetrameric form seems to have a higher calcium and phospholipid-binding affinity than the monomeric annexin II. In the cell, p11 has been localized to the cytoplasmic face of the plasma membrane where the annexin II tetramer is known to exist.

Molekulargewicht: 11 kDa

Pathways: S100 Proteine