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SOD1 Antikörper

SOD1 Reaktivität: Human WB Wirt: Maus Monoclonal G215-1 unconjugated
Produktnummer ABIN967513
  • Target Alle SOD1 Antikörper anzeigen
    SOD1 (Superoxide Dismutase 1, Soluble (SOD1))
    Reaktivität
    • 172
    • 98
    • 90
    • 39
    • 23
    • 17
    • 15
    • 15
    • 15
    • 13
    • 11
    • 10
    • 10
    • 10
    • 10
    • 10
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 192
    • 26
    • 6
    • 4
    • 2
    • 2
    • 1
    Maus
    Klonalität
    • 196
    • 36
    Monoklonal
    Konjugat
    • 101
    • 28
    • 22
    • 12
    • 10
    • 9
    • 7
    • 7
    • 7
    • 7
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser SOD1 Antikörper ist unkonjugiert
    Applikation
    • 212
    • 135
    • 114
    • 59
    • 52
    • 46
    • 31
    • 20
    • 18
    • 14
    • 13
    • 9
    • 6
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Marke
    BD Pharmingen™
    Produktmerkmale
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Recombinant Human CuZnSOD GST Fusion Protein
    Klon
    G215-1
    Isotyp
    IgG2a
    Top Product
    Discover our top product SOD1 Primärantikörper
  • Applikationshinweise
    Applications include western blot analysis (1-2 µg/ml) of over-expressed human CuZnSOD. CuZnSOD is a homodimeric enzyme with a molecular weight of ~32 kDa. The two subunits associate noncovalently and are also stabilized by an intrachain disulfide bond. The molecular weight of each subunit is ~16 kDa.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    0.5 mg/mL
    Buffer
    Aqueous buffered solution containing ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store undiluted at 4°C.
  • Reaume, Elliott, Hoffman, Kowall, Ferrante, Siwek, Wilcox, Flood, Beal, Brown, Scott, Snider: "Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury." in: Nature genetics, Vol. 13, Issue 1, pp. 43-7, (1996) (PubMed).

    Rabizadeh, Gralla, Borchelt, Gwinn, Valentine, Sisodia, Wong, Lee, Hahn, Bredesen: "Mutations associated with amyotrophic lateral sclerosis convert superoxide dismutase from an antiapoptotic gene to a proapoptotic gene: studies in yeast and neural cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 7, pp. 3024-8, (1995) (PubMed).

    Rosen, Siddique, Patterson, Figlewicz, Sapp, Hentati, Donaldson, Goto, ORegan, Deng: "Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis." in: Nature, Vol. 362, Issue 6415, pp. 59-62, (1993) (PubMed).

    Fridovich: "Superoxide dismutases." in: Advances in enzymology and related areas of molecular biology, Vol. 58, pp. 61-97, (1986) (PubMed).

  • Target
    SOD1 (Superoxide Dismutase 1, Soluble (SOD1))
    Andere Bezeichnung
    SOD (SOD1 Produkte)
    Synonyme
    LOC692639 antikoerper, ALS antikoerper, ALS1 antikoerper, IPOA antikoerper, SOD antikoerper, hSod1 antikoerper, homodimer antikoerper, CG11793 antikoerper, Cu antikoerper, Cu-Zn SOD antikoerper, Cu/Zn SOD antikoerper, Cu/Zn sod antikoerper, Cu/Zn superoxide dismutase antikoerper, Cu/ZnSOD antikoerper, CuSOD antikoerper, CuZn SOD antikoerper, CuZn-SOD antikoerper, CuZn-SOD1 antikoerper, CuZnSOD antikoerper, Cu[2+]/Zn[2+]SOD antikoerper, Dmel\\CG11793 antikoerper, G antikoerper, Mn SOD antikoerper, SOD-1 antikoerper, SOD1 antikoerper, Sod-1 antikoerper, Sod1 antikoerper, To antikoerper, To-1 antikoerper, Zn SOD antikoerper, Zn Sod antikoerper, Zn-SOD antikoerper, ZnSod antikoerper, cSOD antikoerper, cSod antikoerper, dSOD1 antikoerper, l(3)108 antikoerper, l(3)68Af' antikoerper, l(3)G antikoerper, sod antikoerper, sod1 antikoerper, CU/ZN-SOD antikoerper, SODC antikoerper, DKFZP469M1833 antikoerper, B430204E11Rik antikoerper, Cu/Zn-SOD antikoerper, Ipo-1 antikoerper, Ipo1 antikoerper, SOD1L1 antikoerper, XSODB antikoerper, als antikoerper, als1 antikoerper, ipoa antikoerper, sod1-a antikoerper, ZSOD antikoerper, cuzn antikoerper, Cu/Zn superoxide dismutase antikoerper, superoxide dismutase 1 antikoerper, Superoxide dismutase 1 antikoerper, superoxide dismutase 1, soluble antikoerper, superoxide dismutase 1 S homeolog antikoerper, Superoxide dismutase [Cu-Zn] antikoerper, superoxide dismutase 1 L homeolog antikoerper, superoxide dismutase [Cu-Zn]-like antikoerper, superoxide dismutase [Cu-Zn] antikoerper, superoxide dismutase Sod1 antikoerper, SOD antikoerper, SOD1 antikoerper, Sod1 antikoerper, sod1 antikoerper, sod1.S antikoerper, sod-1 antikoerper, sod1.L antikoerper, LOC101451855 antikoerper, LOC101115136 antikoerper
    Hintergrund
    The superoxide free radical O2.- is an intermediate form of molecular oxygen that is produced as a natural by-product of respiration and other biological processes Free radicals like O2.- can lead to the formation of additional reactive oxygen species that, in turn, can cause oxidative damage to DNA, protein, and lipid. The superoxide dismutases provide a defense against the damaging effects of O2.- by converting it to O2 + H2O2 (hydrogen peroxide). Hydrogen peroxide is then normally converted to water by either glutathione peroxidase or catalase. SODs are divided up into three types, and thought to evolve from two independent evolutionary lines: The copper- and zinc-containing SOD, CuZnSOD, is expressed in the cytosol of eukaryotic cells, the manganese-containing SOD, MnSOD, is present in bacteria, in the matrix of bacteria, and in mitochondria, and the iron-containing SOD, FeSOD, is found primarily in bacteria and is also expressed in some plants. All of the SODs catalyze the dismutation of O2.- at approximately the same rates. CuZnSOD lacks amino acid sequence homology with MnSOD and FeSOD, suggesting that it evolved independently from the FeSOD/MnSOD family of enzymes. Mutations have been described in the gene encoding CuZnSOD (SOD1) which reduce the activity and halflife of the enzyme. However, the role of these mutations in pathogenesis remains to be elucidated. Clone G215-1 recognizes human CuZnSOD. The antibody was originally characterized by western blot analysis of cells from transgenic mice expressing human CuZnSOD. Recombinant full-length human CuZnSOD GST fusion protein was used as immunogen.
    Synonyms: CuZnSOD Copper/Zinc-Binding Superoxide Dismutase
    Molekulargewicht
    32 kDa
    Pathways
    Sensory Perception of Sound, Transition Metal Ion Homeostasis
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