ITGB1 Antikörper

Produktnummer ABIN967378

Produktdetails anti-ITGB1 Antikörper

Target: ITGB1 (Integrin beta 1 (ITGB1))

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser ITGB1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Functional Studies (Func)

Marke: BD Pharmingen™

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Mouse endothelial cell line

Klon: 9EG7

Isotyp: IgG2a kappa

Anwendungsinformationen

Applikationshinweise: For IHC, we recommend the use of purified 9EG7 mAb in our special formulation for immunohistochemistry.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 4° C.

Referenzen für anti-ITGB1 Antikörper (ABIN967378)

Yashiro, Tai, Toyo-oka, Park, Abe, Hamaoka, Kobayashi, Neben, Fujiwara: "A fundamental difference in the capacity to induce proliferation of naive T cells between CD28 and other co-stimulatory molecules." in: European journal of immunology, Vol. 28, Issue 3, pp. 926-35, (1998) (PubMed).

Driessens, Van Rijthoven, Kemperman, Roos: "Adhesion of lymphoma cells to fibronectin: differential use of alpha 4 beta 1 and alpha 5 beta 1 integrins and stimulation by the 9EG7 mAb against the murine beta 1 integrin subunit." in: Cell adhesion and communication, Vol. 3, Issue 4, pp. 327-36, (1996) (PubMed).

Milner, Edwards, Streuli, Ffrench-Constant: "A role in migration for the alpha V beta 1 integrin expressed on oligodendrocyte precursors." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 16, Issue 22, pp. 7240-52, (1996) (PubMed).

Rich, Van Nood, Lee: "Role of alpha 5 beta 1 integrin in TGF-beta 1-costimulated CD8+ T cell growth and apoptosis." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 157, Issue 7, pp. 2916-23, (1996) (PubMed).

Kassner, Kawaguchi, Hemler: "Minimum alpha chain cytoplasmic tail sequence needed to support integrin-mediated adhesion." in: The Journal of biological chemistry, Vol. 269, Issue 31, pp. 19859-67, (1994) (PubMed).

Lenter, Vestweber: "The integrin chains beta 1 and alpha 6 associate with the chaperone calnexin prior to integrin assembly." in: The Journal of biological chemistry, Vol. 269, Issue 16, pp. 12263-8, (1994) (PubMed).

Springer: "Adhesion receptors of the immune system." in: Nature, Vol. 346, Issue 6283, pp. 425-34, (1990) (PubMed).

Details zu ITGB1

Target: ITGB1 (Integrin beta 1 (ITGB1))

Andere Bezeichnung: CD29 (ITGB1 Produkte)

Hintergrund: The 9EG7 antibody reacts with the 130-kDa integrin beta1 chain (CD29). CD29 is expressed on the cell surface as a heterodimer with one of the distinct integrin alpha chains. With alpha1 through alpha6 (CD49a through CD49f), it forms the VLA-1 through VLA-6 complexes, respectively, and with alphav (CD51), it forms alphavbeta1 integrin. It also associates with the integrin alpha7 alpha8 and alpha9 chains in non-lymphoid tissues. As a result, CD29 has a broad tissue distribution, including lymphocytes, endothelia, smooth muscle, and epithelia. 9EG7 mAb has been shown to inhibit both the alpha6beta1-mediated binding of lymphocytes to endothelial cells and the adhesion mediated by activated, but not unactivated, alpha4beta1-integrin. The source of the immunogen was mouse lymph node-derived endothelial cell line TME.
Synonyms: Integrin beta1 chain

Pathways: Cell-Cell Junction Organization, Regulation of G-Protein Coupled Receptor Protein Signaling, CXCR4-mediated Signaling Events, Signaling of Hepatocyte Growth Factor Receptor, Integrin Complex, SARS-CoV-2 Protein Interaktom