SOCS2 Antikörper (C-Term)

Produktnummer ABIN967065

Dieses Anti-SOCS2-Antikörper ist ein Polyklonal-Antikörper zur Detektion von SOCS2 in WB. Geeignet für Human und Ratte. Dieses Primary Antibody wurde in 4+ Publikationen zitiert.

Kurzübersicht für SOCS2 Antikörper (C-Term) (ABIN967065)

Target: SOCS2 (Suppressor of Cytokine Signaling 2 (SOCS2))

Reaktivität: Human, Ratte

Wirt: Bitte anfragen

Klonalität: Polyklonal

Konjugat: Dieser SOCS2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-SOCS2 Antikörper

Bindungsspezifität: AA 181-198, C-Term

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminal of human SOCS2 (181-198 aa), identical to the related mouse and rat sequence.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: 0.2ml of distilled water will yield a concentration of 500µg/ml.

Buffer: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4

Konservierungsmittel: Thimerosal (Merthiolate), Sodium azide

Lagerung: -20 °C

Referenzen für anti-SOCS2 Antikörper (ABIN967065)

Greenhalgh, Bertolino, Asa, Metcalf, Corbin, Adams, Davey, Nicola, Hilton, Alexander: "Growth enhancement in suppressor of cytokine signaling 2 (SOCS-2)-deficient mice is dependent on signal transducer and activator of transcription 5b (STAT5b)." in: Molecular endocrinology (Baltimore, Md.), Vol. 16, Issue 6, pp. 1394-406, (2002) (PubMed).

Dey, Spence, Nissley, Furlanetto: "Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor." in: The Journal of biological chemistry, Vol. 273, Issue 37, pp. 24095-101, (1998) (PubMed).

Masuhara, Sakamoto, Matsumoto, Suzuki, Yasukawa, Mitsui, Wakioka, Tanimura, Sasaki, Misawa, Yokouchi, Ohtsubo, Yoshimura: "Cloning and characterization of novel CIS family genes." in: Biochemical and biophysical research communications, Vol. 239, Issue 2, pp. 439-46, (1997) (PubMed).

Minamoto, Ikegame, Ueno, Narazaki, Naka, Yamamoto, Matsumoto, Saito, Hosoe, Kishimoto: "Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3." in: Biochemical and biophysical research communications, Vol. 237, Issue 1, pp. 79-83, (1997) (PubMed).

Details zu SOCS2

Target: SOCS2 (Suppressor of Cytokine Signaling 2 (SOCS2))

Andere Bezeichnung: SOCS2

Hintergrund: Suppressor of cytokine signaling 2 is a protein that in humans is encoded by the SOCS2 gene. This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signalling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10 and interferon-gamma (IFN-gamma). The protein encoded by this gene is found to interact with the cytoplasmic domain of insulin-like growth factor 1 receptor (IGF1R), and thus is thought to be involved in the regulation of IGF1R mediated cell signaling. Knockout studies in mice also suggested a regulatory role of this gene in IGF-1 related growth control. By cytogenetic and radiation hybrid mapping, Yandava et al. (1999) mapped the SOCS2 gene to chromosome 12q21.3-q23.

Pathways: JAK-STAT Signalweg, Response to Growth Hormone Stimulus