Notch1 Antikörper (N-Term)

Produktnummer ABIN966679

Produktdetails anti-Notch1 Antikörper

Target: Notch1 (NOTCH1) (Notch 1 (NOTCH1))

Bindungsspezifität: N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Notch1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to near N-terminal residues of human NOTCH1 (Neurogenic locus notch homolog protein 1)

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Lagerung: 4 °C

Referenzen für anti-Notch1 Antikörper (ABIN966679)

Hambleton, Valeyev, Muranyi, Knott, Werner, McMichael, Handford, Downing: "Structural and functional properties of the human notch-1 ligand binding region." in: Structure (London, England : 1993), Vol. 12, Issue 12, pp. 2173-83, (2004) (PubMed).

Vardar, North, Sanchez-Irizarry, Aster, Blacklow: "Nuclear magnetic resonance structure of a prototype Lin12-Notch repeat module from human Notch1." in: Biochemistry, Vol. 42, Issue 23, pp. 7061-7, (2003) (PubMed).

Wu, Sun, Kobayashi, Gao, Griffin: "Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors." in: Molecular and cellular biology, Vol. 22, Issue 21, pp. 7688-700, (2002) (PubMed).

Gray, Mann, Mitsiadis, Henrique, Carcangiu, Banks, Leiman, Ward, Ish-Horowitz, Artavanis-Tsakonas: "Human ligands of the Notch receptor." in: The American journal of pathology, Vol. 154, Issue 3, pp. 785-94, (1999) (PubMed).

Matsuno, Eastman, Mitsiades, Quinn, Carcanciu, Ordentlich, Kadesch, Artavanis-Tsakonas: "Human deltex is a conserved regulator of Notch signalling." in: Nature genetics, Vol. 19, Issue 1, pp. 74-8, (1998) (PubMed).

Ellisen, Bird, West, Soreng, Reynolds, Smith, Sklar: "TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms." in: Cell, Vol. 66, Issue 4, pp. 649-61, (1991) (PubMed).

Details zu Notch1

Target: Notch1 (NOTCH1) (Notch 1 (NOTCH1))

Andere Bezeichnung: NOTCH1 (NOTCH1 Produkte)

Synonyme: notch1 antikoerper, NOTCH1 antikoerper, hn1 antikoerper, tan1 antikoerper, notch antikoerper, xotch antikoerper, xnotch antikoerper, notch-1 antikoerper, xnotch1 antikoerper, TAN1 antikoerper, hN1 antikoerper, 9930111A19Rik antikoerper, Mis6 antikoerper, N1 antikoerper, Tan1 antikoerper, lin-12 antikoerper, NOTCH antikoerper, Xotch antikoerper, notch1-a antikoerper, notch 1 antikoerper, fibropellin-1 antikoerper, Notch homolog 1, translocation-associated (Drosophila) antikoerper, Notch homolog 1, translocation-associated antikoerper, notch 1 S homeolog antikoerper, notch1 antikoerper, LOC100631526 antikoerper, NOTCH1 antikoerper, Notch1 antikoerper, notch1.S antikoerper

Hintergrund: NOTCH1 (Neurogenic locus notch homolog protein 1) functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. NOTCH1 affects the implementation of differentiation, proliferation and apoptotic programs. NOTCH1 may be important for normal lymphocyte function. In altered form, NOTCH1 may contribute to transformation or progression in some T-cell neoplasms. NOTCH1 is involved in the maturation of both CD4+ and CD8+ cells in the thymus. NOTCH1 may be important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, may function as a receptor for neuronal DNER and may be involved in the differentiation of Bergmann glia. NOTCH1 is synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase in the trans-Golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin dependent gamma-secretase to release a notch-derived peptide containing the intracellular domain (NICD) from the membrane. NOTCH1 truncation is associated with T-cell acute lymphoblastic leukemia.
Synonyms: TAN1(Translocation-associated notch protein TAN-1)

Pathways: Notch Signalweg, Stem Cell Maintenance, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development