CCL2 Antikörper

Produktnummer ABIN966545

Es sind 3+ Publikationen für dieses Produkt verfügbar. Der Monoklonal anti-CCL2 Antikörper wird verwendet zum Nachweis von CCL2 in Proben von Human. Er wurde validiert für WB und ELISA.

Kurzübersicht für CCL2 Antikörper (ABIN966545)

Target: CCL2 (Chemokine (C-C Motif) Ligand 2 (CCL2))

Reaktivität: Human

Wirt: Bitte anfragen

Klonalität: Monoklonal

Konjugat: Dieser CCL2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-CCL2 Antikörper

Spezifität: Ni-NTA purified recombinant human MCP-1 expressed in E.Coli strain BL21 (DE3).

Aufreinigung: Antibodies are purified by protein A affinity chromatography

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Dilution: Western Blot: 1:500-1,000
ELISA: 1,000-2,000.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Lagerung: -20 °C

Referenzen für anti-CCL2 Antikörper (ABIN966545)

Yoshimura, Leonard: "Human monocyte chemoattractant protein-1 (MCP-1)." in: Advances in experimental medicine and biology, Vol. 305, pp. 47-56, (1992) (PubMed).

Rollins, Morton, Ledbetter, Eddy, Shows: "Assignment of the human small inducible cytokine A2 gene, SCYA2 (encoding JE or MCP-1), to 17q11.2-12: evolutionary relatedness of cytokines clustered at the same locus." in: Genomics, Vol. 10, Issue 2, pp. 489-92, (1991) (PubMed).

Yoshimura, Yuhki, Moore, Appella, Lerman, Leonard: "Human monocyte chemoattractant protein-1 (MCP-1). Full-length cDNA cloning, expression in mitogen-stimulated blood mononuclear leukocytes, and sequence similarity to mouse competence gene JE." in: FEBS letters, Vol. 244, Issue 2, pp. 487-93, (1989) (PubMed).

Details zu CCL2

Target: CCL2 (Chemokine (C-C Motif) Ligand 2 (CCL2))

Andere Bezeichnung: MCP-1

Hintergrund: Monocyte chemoattractant protein-1 (MCP-1) is a member of the chemokine-beta family of cytokines. The protein is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. It may play a inprotant role in the initiation and/or progression of pulmonary hypertension (PH). Blockade of a systemic MCP-1 signal pathway in vivo may prevent PH.

Pathways: Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, ER-Nucleus Signaling, Unfolded Protein Response, Phosphorylierungen bei SARS-CoV-2 Infektion