Inhibin alpha Antikörper

Produktnummer ABIN966402

Produktdetails anti-Inhibin alpha Antikörper

Target: Inhibin alpha (INHA) (Inhibin, alpha (INHA))

Reaktivität: Human

Wirt: Bitte anfragen

Klonalität: Monoklonal

Konjugat: Dieser Inhibin alpha Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Spezifität: Ni-NTA purified truncated recombinant INHA expressed in E. Coli strain BL21 (DE3)

Aufreinigung: Antibodies are purified by protein A affinity chromatography

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Western Blot: 1: 500- 1: 1,000
IHC(P): 1: 1,000- 1: 2,000
ELISA: Propose dilution 1: 10,000 Determining optimal working dilutions by titration test.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Lagerung: -20 °C

Referenzen für anti-Inhibin alpha Antikörper (ABIN966402)

Knight: "Roles of inhibins, activins, and follistatin in the female reproductive system." in: Frontiers in neuroendocrinology, Vol. 17, Issue 4, pp. 476-509, (1997) (PubMed).

Fahy, Wilson, Beard, Groome, Knight et al.: "Changes in inhibin-A (alpha-beta A dimer) and total alpha inhibin in the peripheral circulation and ovaries of rats after gonadotrophin-induced follicular development and during the normal oestrous ..." in: The Journal of endocrinology, Vol. 147, Issue 2, pp. 271-83, (1996) (PubMed).

Lambert-Messerlian, Crowley, Schneyer: "Extragonadal alpha-inhibin precursor proteins circulate in human male serum." in: The Journal of clinical endocrinology and metabolism, Vol. 80, Issue 10, pp. 3043-9, (1995) (PubMed).

Mayo, Cerelli, Spiess, Rivier, Rosenfeld, Evans, Vale: "Inhibin A-subunit cDNAs from porcine ovary and human placenta." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 83, Issue 16, pp. 5849-53, (1986) (PubMed).

Details zu Inhibin alpha

Target: Inhibin alpha (INHA) (Inhibin, alpha (INHA))

Andere Bezeichnung: INHA (INHA Produkte)

Hintergrund: INHA(A-inhibin subunit precursor, inhibin alpha subunit ),also called inhibin(alpha) ,which is located on chromosome 2q33-q36. Inhibin is a gonadal protein that preferentially suppresses the secretion of pituitary follicle-stimulating hormone (FSH). Inhibin comprises of two subunits,Inhibin A and B. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa cell tumors and can therefore be used as a marker for primary as well as recurrent disease. In addition to their role in endocrine feedback in the reproductive sytem, inhibins subserve local regulatory roles in numerous extragonadal tissues, including brain, adrenal,bone marrow, placenta, and most notably anterior pituitary. Inhibin alpha subunit gene expression is down regulated in human prostate cancer, suggesting a tumor suppressive role.

Gen-ID: 3623

Pathways: Peptide Hormone Metabolism, Hormone Activity, Negative Regulation of Hormone Secretion