USP7 Antikörper

Produktnummer ABIN966249

Dieses Anti-USP7-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von USP7 in WB und ELISA. Geeignet für Human. Dieses Primary Antibody wurde in 3+ Publikationen zitiert.

Kurzübersicht für USP7 Antikörper (ABIN966249)

Target: USP7 (Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser USP7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Klon: 5F11

Produktdetails anti-USP7 Antikörper

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of human HAUSP expressed in E. Coli.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Western Bloting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Referenzen für anti-USP7 Antikörper (ABIN966249)

Kotoula, Krikelis, Karavasilis, Koletsa, Eleftheraki, Televantou, Christodoulou, Dimoudis, Korantzis, Pectasides, Syrigos, Kosmidis, Fountzilas: "Expression of DNA repair and replication genes in non-small cell lung cancer (NSCLC): a role for thymidylate synthetase (TYMS)." in: BMC cancer, Vol. 12, Issue 1, pp. 342, (2012) (PubMed).

Abély: "[Treatment of airway inflammation in cystic fibrosis]." in: Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, Vol. 14, Issue 11, pp. 1350-5, (2007) (PubMed).

MILLER: "Observations on a case of probable bone marrow anthracosis." in: Blood, Vol. 14, pp. 1350-3 (PubMed).

Details zu USP7

Target: USP7 (Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7))

Andere Bezeichnung: HAUSP

Hintergrund: USP7 or HAUSP is a ubiquitin specific protease or a deubiquitylating enzyme that cleaves ubiquitin from its substrates. Since ubiquitylation (polyubiquitination) is most commonly associated with the stability and degradation of cellular proteins, HAUSP acitivity generally stabilizes its substrate proteins. HAUSP is most popularly known as a direct antagonist of Mdm2, the E3 ubiquitin ligase for the tumor suppressor protein, p53.Normally, p53 levels are kept low in part due to Mdm2mediated ubiquitylation and degradation of p53. Interestingly, in response to oncogenic insults, HAUSP can deubiquitinate p53 and protect p53 from Mdm2-mediated degradation, indicating that it may possess a tumor suppressor function for the immediate stabilization of p53 in response to stress. Another important role of HAUSP function involves the oncogenic stabilization of p53. Oncogenes such as Myc and E1A are thought to activate p53 through a p19 alternative reading frame (p19ARF, also called ARF)dependent pathway, although some evidence suggests ARF is not essential in this process. An intriguing possibility is that HAUSP provides an alternative pathway for safeguarding the cell against oncogenic insults.
Synonyms: TEF1, HAUSP, USP7

Molekulargewicht: 128kDa

Gen-ID: 7874