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CD80 Antikörper (N-Term)

CD80 Reaktivität: Human WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN965820
  • Target Alle CD80 Antikörper anzeigen
    CD80
    Bindungsspezifität
    • 16
    • 15
    • 12
    • 10
    • 8
    • 6
    • 6
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 57-71, N-Term
    Reaktivität
    • 139
    • 123
    • 44
    • 8
    • 3
    • 3
    • 1
    • 1
    • 1
    Human
    Wirt
    • 88
    • 71
    • 26
    • 24
    • 23
    • 1
    • 1
    Kaninchen
    Klonalität
    • 154
    • 77
    • 2
    Polyklonal
    Konjugat
    • 90
    • 20
    • 19
    • 17
    • 15
    • 6
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CD80 Antikörper ist unkonjugiert
    Applikation
    • 141
    • 94
    • 70
    • 41
    • 34
    • 22
    • 14
    • 14
    • 13
    • 13
    • 12
    • 11
    • 11
    • 6
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Immunogen
    A synthetic peptide corresponding to a sequence at the N-terminal of human CD80 (57-71aa), identical to the related mouse and rat sequence.
    Top Product
    Discover our top product CD80 Primärantikörper
  • Applikationshinweise
    WB: The detection limit for CD80/ B7-1 is approximately 2.5ng/lane under non-reducing and reducing conditions.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Rekonstitution
    0.2ml of distilled water will yield a concentration of 500µg/ml.
    Buffer
    Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4
    Konservierungsmittel
    Thimerosal (Merthiolate), Sodium azide
    Lagerung
    -20 °C
  • Stamper, Zhang, Tobin, Erbe, Ikemizu, Davis, Stahl, Seehra, Somers, Mosyak: "Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses." in: Nature, Vol. 410, Issue 6828, pp. 608-11, (2001) (PubMed).

    Peach, Bajorath, Naemura, Leytze, Greene, Aruffo, Linsley: "Both extracellular immunoglobin-like domains of CD80 contain residues critical for binding T cell surface receptors CTLA-4 and CD28." in: The Journal of biological chemistry, Vol. 270, Issue 36, pp. 21181-7, (1995) (PubMed).

  • Target
    CD80
    Andere Bezeichnung
    CD80 (CD80 Produkte)
    Synonyme
    B7 antikoerper, B7-1 antikoerper, B7.1 antikoerper, BB1 antikoerper, CD28LG antikoerper, CD28LG1 antikoerper, LAB7 antikoerper, B71 antikoerper, Cd28l antikoerper, Ly-53 antikoerper, Ly53 antikoerper, MIC17 antikoerper, TSA1 antikoerper, CD80 molecule antikoerper, Cd80 molecule antikoerper, CD80 antigen antikoerper, CD80 antikoerper, Cd80 antikoerper
    Hintergrund
    Cluster of Differentiation 80 (also CD80 and B7-1) is a protein found on activated B cells and monocytes that provides a costimulatory signal necessary for T cell activation and survival. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD80 works in tandem with CD86 to prime T cells. The CD80 genes encode B7-1 which are structurally similar members of the immunoglobulin superfamily expressed on a variety of hematopoietic cell types. Reeves et al. (1997) stated that B7-1 and B7-2 provide a costimulatory signal to T cells by interacting with CD28 and CTLA4.
    Pathways
    T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints
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