CD80 Antikörper (N-Term)

Produktnummer ABIN965820

Dieses Anti-CD80-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von CD80 in WB. Geeignet für Human. Dieses Primary Antibody wurde in 2+ Publikationen zitiert.

Kurzübersicht für CD80 Antikörper (N-Term) (ABIN965820)

Target: CD80

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CD80 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-CD80 Antikörper

Bindungsspezifität: AA 57-71, N-Term

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminal of human CD80 (57-71aa), identical to the related mouse and rat sequence.

Anwendungsinformationen

Applikationshinweise: WB: The detection limit for CD80/ B7-1 is approximately 2.5ng/lane under non-reducing and reducing conditions.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: 0.2ml of distilled water will yield a concentration of 500µg/ml.

Buffer: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4

Konservierungsmittel: Thimerosal (Merthiolate), Sodium azide

Lagerung: -20 °C

Referenzen für anti-CD80 Antikörper (ABIN965820)

Stamper, Zhang, Tobin, Erbe, Ikemizu, Davis, Stahl, Seehra, Somers, Mosyak: "Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses." in: Nature, Vol. 410, Issue 6828, pp. 608-11, (2001) (PubMed).

Peach, Bajorath, Naemura, Leytze, Greene, Aruffo, Linsley: "Both extracellular immunoglobin-like domains of CD80 contain residues critical for binding T cell surface receptors CTLA-4 and CD28." in: The Journal of biological chemistry, Vol. 270, Issue 36, pp. 21181-7, (1995) (PubMed).

Details zu CD80

Target: CD80

Andere Bezeichnung: CD80

Hintergrund: Cluster of Differentiation 80 (also CD80 and B7-1) is a protein found on activated B cells and monocytes that provides a costimulatory signal necessary for T cell activation and survival. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD80 works in tandem with CD86 to prime T cells. The CD80 genes encode B7-1 which are structurally similar members of the immunoglobulin superfamily expressed on a variety of hematopoietic cell types. Reeves et al. (1997) stated that B7-1 and B7-2 provide a costimulatory signal to T cells by interacting with CD28 and CTLA4.

Pathways: T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints