c-FOS Antikörper (Middle Region)

Produktnummer ABIN965712

Dieses Anti-c-FOS-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von c-FOS in WB. Geeignet für Human. Dieses Primary Antibody wurde in 3+ Publikationen zitiert.

Kurzübersicht für c-FOS Antikörper (Middle Region) (ABIN965712)

Target: c-FOS (c-Fos) (c-Fos)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser c-FOS Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-c-FOS Antikörper

Bindungsspezifität: Middle Region

Kreuzreaktivität: Maus, Ratte (Rattus)

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Produktmerkmale: Rabbit IgG polyclonal antibody for Proto-oncogene c-Fos (FOS) detection. Tested with WB in Human, Mouse, Rat.

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human C-FOS, identical to the related rat and mouse sequences.< br/>Immunogen was affinity purified.

Isotyp: IgG

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 µg/mL.

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide, Thimerosal (Merthiolate)

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: At -20 °C for one year. After reconstitution, at 4 °C for one month. It can also be aliquotted and stored frozen at -20 °C for a longer time.

Referenzen für anti-c-FOS Antikörper (ABIN965712)

Grigoriadis, Wang, Wagner: "Fos and bone cell development: lessons from a nuclear oncogene." in: Trends in genetics : TIG, Vol. 11, Issue 11, pp. 436-41, (1996) (PubMed).

Saez, Rutberg, Mueller, Oppenheim, Smoluk, Yuspa, Spiegelman: "c-fos is required for malignant progression of skin tumors." in: Cell, Vol. 82, Issue 5, pp. 721-32, (1995) (PubMed).

Barker, Rabin, Watson, Breg, Ruddle, Verma: "Human c-fos oncogene mapped within chromosomal region 14q21----q31." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 81, Issue 18, pp. 5826-30, (1984) (PubMed).

Details zu c-FOS

Target: c-FOS (c-Fos) (c-Fos)

Andere Bezeichnung: Proto-oncogene c-Fos

Hintergrund: The human oncogene c-fos is cellular homolog of the transforming gene of Finkel-Biskis-Jinkins (FBJ) murine osteosarcoma virus which was mapped to a single human chromosome. c-Fos is encoded by the FOS gene. FOS was the first transcription factor identified that has a critical function in regulating the development of cells destined to form and maintain the skeleton. FOS is also a major component of the activator protein-1 (AP-1) transcription factor complex, which includes members of the JUN family. c-fos is a major nuclear target for signal transduction pathways involved in the regulation of cell growth, differentiation, and transformation. Using transgenic and knockout mice, Grigoriadis et al. (1995) established a unique role for the proto-oncogene and nuclear transcription factor, Fos, in regulating the differentiation and activity of specific bone cell populations, both during normal development and in bone disease.

Pathways: S100 Proteine