SRRT Antikörper (C-Term)

Produktnummer ABIN965596

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch SRRT in IHC. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für SRRT Antikörper (C-Term) (ABIN965596)

Target: SRRT (Serrate RNA Effector Molecule Homolog (SRRT))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SRRT Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Produktdetails anti-SRRT Antikörper

Bindungsspezifität: C-Term

Aufreinigung: Purified by antigen-specific affinity chromatography.

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human ARS2 (Arsenite-resistance protein 2)

Anwendungsinformationen

Applikationshinweise: ELISA, Western blotting: 1µg/ml for 2hrs.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: This antibody is stored in PBS, 50% glycerol

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Details zu SRRT

Target: SRRT (Serrate RNA Effector Molecule Homolog (SRRT))

Andere Bezeichnung: ARS2

Hintergrund: ARS2(Arsenite-resistance protein 2) confers arsenite resistance The protein belongs to the ARS2 family. Arsenic is a human carcinogen whose mechanism of action is unknown. The arsenite acts as a comutagen by interfering with DNA repair. Two genes, ASR1(Arsenite-resistance protein 1) and ASR2(Arsenite-resistance protein 2), confer arsenite resistance to arsenite-sensitive cells. ASR1 shows almost complete homology with the rat fau gene, a tumor suppressor gene which contains a ubiquitinlike region fused to S30 ribosomal protein. Arsenite inhibits ubiquitin-dependent proteolysis. The tumor suppressor fau gene product or some other aspect of the ubiquitin system may be a target for arsenic toxicity and that disruption of the ubiquitin system may contribute to the genotoxicity and carcinogenicity of arsenite.

Pathways: Notch Signalweg, Stem Cell Maintenance