Androgen Receptor Antikörper (AA 689-919)

Produktnummer ABIN965588

Der Maus Monoklonal Anti-Androgen Receptor-Antikörper wurde für WB und ELISA validiert. Er ist geeignet, Androgen Receptor in Proben von Human zu detektieren. Es sind 2+ Publikationen verfügbar.

Kurzübersicht für Androgen Receptor Antikörper (AA 689-919) (ABIN965588)

Target: Androgen Receptor (AR)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Androgen Receptor Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Klon: 1A9D12

Produktdetails anti-Androgen Receptor Antikörper

Bindungsspezifität: AA 689-919

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of AR (aa689-919) expressed in E. Coli.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Western Bloting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Referenzen für anti-Androgen Receptor Antikörper (ABIN965588)

Zong, Chi, Wang, Yang, Zhang, Chen, Jiang, Li, Hong, Wang, Yun, Gu: "Cyclin D3/CDK11p58 complex is involved in the repression of androgen receptor." in: Molecular and cellular biology, Vol. 27, Issue 20, pp. 7125-42, (2007) (PubMed).

Lindström, Wiklund, Adami, Bälter, Adolfsson, Grönberg: "Germ-line genetic variation in the key androgen-regulating genes androgen receptor, cytochrome P450, and steroid-5-alpha-reductase type 2 is important for prostate cancer development." in: Cancer research, Vol. 66, Issue 22, pp. 11077-83, (2006) (PubMed).

Details zu Androgen Receptor

Target: Androgen Receptor (AR)

Andere Bezeichnung: AR

Hintergrund: AR: androgen receptor. The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described.
Synonyms: KD, AIS, TFM, DHTR, SBMA

Gen-ID: 367

Pathways: Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, Chromatin Binding