PYM Antikörper (N-Term)

Produktnummer ABIN955577

Der Kaninchen Polyklonal Anti-PYM-Antikörper wurde für WB, IHC (p) und EIA validiert. Er ist geeignet, PYM in Proben von Human und Maus zu detektieren.

Kurzübersicht für PYM Antikörper (N-Term) (ABIN955577)

Target: PYM (WIBG) (Partner of Y14 and mago (WIBG))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PYM Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-PYM Antikörper

Bindungsspezifität: AA 15-44, N-Term

Spezifität: This antibody detects WIBG / PYM (N-term).

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse

Aufreinigung: Protein A column followed by peptide affinity purification

Immunogen: KLH conjugated synthetic peptide between 15-44 amino acids from the N-terminal region of human WIBG

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer.

Details zu PYM

Target: PYM (WIBG) (Partner of Y14 and mago (WIBG))

Andere Bezeichnung: WIBG / PYM

Hintergrund: Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmarks for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as a EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions. May bind RNA, the relevance of RNA-binding remains unclear in vivo, RNA-binding was detected by PubMed:14968132, while PubMed:19410547 did not detect RNA-binding activity independently of the EJC.Synonyms: Partner of Y14 and mago, Protein wibg homolog

Gen-ID: 84305

NCBI Accession: NP_001137325