PYM Antikörper

Produktnummer ABIN7269181

Produktdetails anti-PYM Antikörper

Target: PYM (WIBG) (Partner of Y14 and mago (WIBG))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PYM Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Verwendungszweck: PYM1 Rabbit pAb

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant protein of human PYM1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IF,1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu PYM

Target: PYM (WIBG) (Partner of Y14 and mago (WIBG))

Andere Bezeichnung: PYM1 (WIBG Produkte)

Synonyme: BEST:HL05757 antikoerper, CG10330 antikoerper, CG30176 antikoerper, Dmel\\CG30176 antikoerper, PYM antikoerper, Pym antikoerper, UD3 antikoerper, A030010B05Rik antikoerper, zgc:65891 antikoerper, zgc:77281 antikoerper, Partner of Y14 and Mago antikoerper, Wibg protein antikoerper, PYM homolog 1, exon junction complex associated factor L homeolog antikoerper, PYM homolog 1, exon junction complex associated factor antikoerper, Pym antikoerper, wibg antikoerper, pym1.L antikoerper, PYM1 antikoerper, Pym1 antikoerper, pym1 antikoerper

Hintergrund: Key regulator of the exon junction complex (EJC, a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD or translation. Acts as an EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions. May bind RNA, the relevance of RNA-binding remains unclear in vivo, RNA-binding was detected by PubMed:14968132, while PubMed:19410547 did not detect RNA-binding activity independently of the EJC.,PYM, WIBG,Epigenetics & Nuclear Signaling,PYM1

Gen-ID: 84305

UniProt: Q9BRP8