SSRP1 Antikörper (C-Term)

Produktnummer ABIN954958

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch SSRP1 in WB und EIA. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für SSRP1 Antikörper (C-Term) (ABIN954958)

Target: SSRP1 (Structure Specific Recognition Protein 1 (SSRP1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SSRP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-SSRP1 Antikörper

Bindungsspezifität: AA 489-518, C-Term

Spezifität: This antibody recognizes Human SSRP1 / FACT80 (C-term).

Aufreinigung: Affinity Chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 489-518 amino acids from the C-terminal region of Human SSRP1. Genename: SSRP1

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: PBS, 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu SSRP1

Target: SSRP1 (Structure Specific Recognition Protein 1 (SSRP1))

Andere Bezeichnung: SSRP1 / FACT80

Hintergrund: The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described, but its full-length nature is not known.Synonyms: Chromatin-specific transcription elongation factor 80 kDa subunit, FACT 80 kDa subunit, FACT complex subunit SSRP1, FACTp80, Facilitates chromatin transcription complex subunit SSRP1, Recombination signal sequence recognition protein 1, Structure-specific recognition protein 1, T160

Molekulargewicht: 81075 Da

Gen-ID: 6749

NCBI Accession: NP_003137

Pathways: Chromatin Binding