GSAP Antikörper (C-Term)

Produktnummer ABIN954149

Der Kaninchen Polyklonal Anti-GSAP-Antikörper wurde für WB, IHC (p) und EIA validiert. Er ist geeignet, GSAP in Proben von Human zu detektieren.

Kurzübersicht für GSAP Antikörper (C-Term) (ABIN954149)

Target: GSAP (PION) (Pigeon Homolog (PION))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GSAP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-GSAP Antikörper

Bindungsspezifität: AA 536-565, C-Term

Spezifität: This antibody recognizes Human PION (C-term).

Aufreinigung: Affinity Chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 536-565 amino acids from the C-terminal region of human PION

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu GSAP

Target: GSAP (PION) (Pigeon Homolog (PION))

Andere Bezeichnung: PION / GSAP

Hintergrund: Accumulation of neurotoxic amyloid-beta is a major hallmark of Alzheimer disease (AD, MIM 104300). Formation of amyloid-beta is catalyzed by gamma-secretase (see PSEN1, MIM 104311), a protease with numerous substrates. PION, or GSAP, selectively increases amyloid-beta production through a mechanism involving its interaction with both gamma-secretase and its substrate, the amyloid-beta precursor protein (APP, MIM 104760) C-terminal fragment (APP-CTF) (He et al., 2010 [PubMed 20811458]).Synonyms: Gamma-secretase-activating protein, Protein pigeon homolog

Molekulargewicht: 97802 Da

Gen-ID: 54103

NCBI Accession: NP_059135