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PAX5 Antikörper (Middle Region)

Dieses Anti-PAX5-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von PAX5 in WB und EIA. Geeignet für Human.
Produktnummer ABIN954009

Kurzübersicht für PAX5 Antikörper (Middle Region) (ABIN954009)

Target

Alle PAX5 Antikörper anzeigen
PAX5 (Paired Box 5 (PAX5))

Reaktivität

  • 113
  • 60
  • 10
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
Human

Wirt

  • 85
  • 18
  • 10
  • 1
Kaninchen

Klonalität

  • 74
  • 40
Polyklonal

Konjugat

  • 66
  • 7
  • 6
  • 5
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser PAX5 Antikörper ist unkonjugiert

Applikation

  • 66
  • 46
  • 30
  • 19
  • 16
  • 14
  • 13
  • 11
  • 8
  • 5
  • 4
  • 4
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), Enzyme Immunoassay (EIA)
  • Bindungsspezifität

    • 15
    • 9
    • 8
    • 6
    • 6
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 185-215, Middle Region

    Spezifität

    This antibody reacts to PAX5.

    Kreuzreaktivität (Details)

    Species reactivity (tested):Human.

    Aufreinigung

    Affinity chromatography on Protein A

    Immunogen

    KLH conjugated synthetic peptide between 185-215 amino acids from the Central region of human PAX5

    Isotyp

    Ig Fraction
  • Applikationshinweise

    Optimal working dilution should be determined by the investigator.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    0.25 mg/mL

    Buffer

    PBS, 0.09 % (W/V) sodium azide

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Avoid repeated freezing and thawing.

    Lagerung

    4 °C/-20 °C

    Informationen zur Lagerung

    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target

    PAX5 (Paired Box 5 (PAX5))

    Andere Bezeichnung

    PAX5

    Hintergrund

    This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9,14)(p13,q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternatively spliced transcript variants encoding different isoforms have been described but their biological validity has not been determined.Synonyms: B-cell-specific transcription factor, BSAP, Paired box protein Pax-5, Pax-5

    Molekulargewicht

    42149 Da

    Gen-ID

    5079

    NCBI Accession

    NP_057953
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