KDM4B Antikörper (C-Term)
Kurzübersicht für KDM4B Antikörper (C-Term) (ABIN952974)
Target
Alle KDM4B Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 287-316, C-Term
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Spezifität
- This antibody recognizes Human and Mouse JMJD2B (Thr305)
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Aufreinigung
- Protein A column, followed by peptide affinity purification
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Immunogen
- KLH conjugated synthetic peptide between 287~316 amino acids from the C-terminal region of human JMJD2B
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Isotyp
- Ig Fraction
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Applikationshinweise
- Optimal working dilution should be determined by the investigator.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Konzentration
- 0.25 mg/mL
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Buffer
- PBS containing 0.09 % (W/V) Sodium Azide as preservative
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Handhabung
- Avoid repeated freezing and thawing.
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Lagerung
- 4 °C/-20 °C
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Informationen zur Lagerung
- Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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: "The histone demethylases JMJD1A and JMJD2B are transcriptional targets of hypoxia-inducible factor HIF." in: The Journal of biological chemistry, Vol. 283, Issue 52, pp. 36542-52, (2008) (PubMed).
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- KDM4B (Lysine (K)-Specific Demethylase 4B (KDM4B))
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Andere Bezeichnung
- JMJD2B / KDM4B
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Hintergrund
- Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate.Synonyms: JHDM3B, JmjC domain-containing histone demethylation protein 3B, Jumonji domain-containing protein 2B, KIAA0876, Lysine-specific demethylase 4B
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Molekulargewicht
- 121897 Da
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Gen-ID
- 23030
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NCBI Accession
- NP_055830
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Pathways
- Warburg Effekt
Target
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