Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch INHBB in WB, IHC (p) und EIA. Er zeigt eine Reaktivität gegenüber Human und Maus und wurde in 1 Publikation erwähnt.
Suggested dilutions: ELISA: 1/1000. Western Blot: 1/100-1/500. Immunohistochemistry on Paraffin Sections: 1/10-1/50.
Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Konzentration
0.25 mg/mL
Buffer
PBS containing 0.09 % (W/V) Sodium Azide as preservative
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung
Avoid repeated freezing and thawing.
Lagerung
4 °C/-20 °C
Informationen zur Lagerung
Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Zhong, Pons, Poirier, Jiang, Liu, Sandusky, Shahda, Nakeeb, Schmidt, House, Ceppa, Zyromski, Liu, Jiang, Couch, Koniaris, Zimmers: "The systemic activin response to pancreatic cancer: implications for effective cancer cachexia therapy." in: Journal of cachexia, sarcopenia and muscle, Vol. 10, Issue 5, pp. 1083-1101, (2020) (PubMed).
Target
INHBB
(Inhibin, beta B (INHBB))
Andere Bezeichnung
Inhibin beta B Chain (INHBB)
Hintergrund
The inhibin beta B subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta B subunit forms a homodimer, activin B, and also joins with the beta A subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion.Synonyms: Activin B, Activin beta-B chain