Endothelin 3 Antikörper (C-Term)

Produktnummer ABIN952025

Der Kaninchen Polyklonal anti-Endothelin 3 Antikörper wird verwendet zum Nachweis von Endothelin 3 in Proben von Human. Er wurde validiert für WB und EIA.

Kurzübersicht für Endothelin 3 Antikörper (C-Term) (ABIN952025)

Target: Endothelin 3 (EDN3)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Endothelin 3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-Endothelin 3 Antikörper

Bindungsspezifität: AA 175-205, C-Term

Spezifität: This antibody recognizes Human Endothelin-3 (C-term).

Aufreinigung: Affinity Chromatography on Protein A

Immunogen: conjugated synthetic peptide between 175-205 amino acids from the C-terminal region of Human Endothelin-3. Genename: EDN3

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C to -80 °C for longer.

Details zu Endothelin 3

Target: Endothelin 3 (EDN3)

Andere Bezeichnung: Endothelin-3

Hintergrund: The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Four alternatively spliced transcript variants encoding three distinct isoforms have been observed.Synonyms: EDN3, ET-3, ET3, HSCR4, MGC15067, MGC61498, PPET3, Preproendothelin-3, WS4B

Molekulargewicht: 25454 Da

Gen-ID: 1908

Pathways: Hormone Transport, Negative Regulation of Hormone Secretion, Regulation of Systemic Arterial Blood Pressure by Hormones