Endothelin 3 Antikörper (C-Term)

Produktnummer ABIN655169

Der Kaninchen Polyklonal anti-Endothelin 3 Antikörper wird verwendet zum Nachweis von Endothelin 3 in Proben von Human. Er wurde validiert für WB.

Kurzübersicht für Endothelin 3 Antikörper (C-Term) (ABIN655169)

Target: Endothelin 3 (EDN3)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Endothelin 3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB18967

Produktdetails anti-Endothelin 3 Antikörper

Bindungsspezifität: AA 168-197, C-Term

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This EDN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 168-197 amino acids from the C-terminal region of human EDN3.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Details zu Endothelin 3

Target: Endothelin 3 (EDN3)

Andere Bezeichnung: EDN3

Hintergrund: The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Four alternatively spliced transcript variants encoding three distinct isoforms have been observed.

Molekulargewicht: 25454

Gen-ID: 1908

NCBI Accession: NP_000105, NP_996915, NP_996916, NP_996917

UniProt: P14138

Pathways: Hormone Transport, Negative Regulation of Hormone Secretion, Regulation of Systemic Arterial Blood Pressure by Hormones