COX10 Antikörper (C-Term)

Produktnummer ABIN951674

Produktdetails anti-COX10 Antikörper

Target: COX10 (Cytochrome C Oxidase Assembly Homolog 10 (COX10))

Bindungsspezifität: AA 386-414, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser COX10 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Spezifität: This antibody reacts to COX10.

Kreuzreaktivität (Details): Species reactivity (tested):Human.

Aufreinigung: Affinity chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 386-414 amino acids from the C-terminal region of human COX1

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: PBS, 0.09 % (W/V) sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu COX10

Target: COX10 (Cytochrome C Oxidase Assembly Homolog 10 (COX10))

Andere Bezeichnung: COX10 (COX10 Produkte)

Synonyme: 2410004F01Rik antikoerper, AU042636 antikoerper, im:7145568 antikoerper, im:7157205 antikoerper, wu:fb18a03 antikoerper, F4I1.50 antikoerper, F4I1_50 antikoerper, cytochrome c oxidase 10 antikoerper, Cox10 antikoerper, cytochrome c oxidase assembly protein 10 antikoerper, COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor antikoerper, COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor L homeolog antikoerper, COX10, heme A:farnesyltransferase cytochrome c oxidase assembly factor antikoerper, cytochrome c oxidase 10 antikoerper, protoheme IX farnesyltransferase, mitochondrial antikoerper, Cox10 antikoerper, cox10 antikoerper, cox10.L antikoerper, COX10 antikoerper, LOC100732273 antikoerper

Hintergrund: Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes heme A:farnesyltransferase, which is not a structural subunit but required for the expression of functional COX and functions in the maturation of the heme A prosthetic group of COX. This protein is predicted to contain 7-9 transmembrane domains localized in the mitochondrial inner membrane. A gene mutation, which results in the substitution of a lysine for an asparagine (N204K), is identified to be responsible for cytochrome c oxidase deficiency. In addition, this gene is disrupted in patients with CMT1A (Charcot-Marie-Tooth type 1A) duplication and with HNPP (hereditary neuropathy with liability to pressure palsies) deletion.Synonyms: COX-10, Heme O synthase, mitochondrial Protoheme IX farnesyltransferase

Molekulargewicht: 48910 Da

Gen-ID: 1352

NCBI Accession: NP_001294