COX10 Antikörper (Internal Region)

Produktnummer ABIN7219600

Der Kaninchen Polyklonal anti-COX10 Antikörper wird verwendet zum Nachweis von COX10 in Proben von Human und Maus. Er wurde validiert für WB und ELISA.

Kurzübersicht für COX10 Antikörper (Internal Region) (ABIN7219600)

Target: COX10 (Cytochrome C Oxidase Assembly Homolog 10 (COX10))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser COX10 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-COX10 Antikörper

Bindungsspezifität: Internal Region

Verwendungszweck: Rabbit Anti-COX10 Polyclonal Antibody

Spezifität: COX10 Polyclonal Antibody detects endogenous levels of COX10 protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the Internal region of human COX10

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,ELISA 1:10000,Not yet tested in other applications.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu COX10

Target: COX10 (Cytochrome C Oxidase Assembly Homolog 10 (COX10))

Andere Bezeichnung: COX10

Hintergrund: COX10, Protoheme IX farnesyltransferase, mitochondrial, Heme O synthaseCytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. COX10 encodes heme A: farnesyltransferase, which is not a structural subunit but required for the expression of functional COX and functions in the maturation of the heme A prosthetic group of COX. COX10, heme A: farnesyltransferase cytochrome c oxidase assembly factor is predicted to contain 7-9 transmembrane domains localized in the mitochondrial inner membrane. A gene mutation, which results in the substitution of a lysine for an asparagine (N204K), is identified to be responsible for cytochrome c oxidase deficiency. In addition, this gene is disrupted in patients with CMT1A (Charcot-Marie-Tooth type 1A) duplication and with HNPP (hereditary neuropathy with liability to pressure palsies) deletion.

Molekulargewicht: 49kD

Gen-ID: 1352

UniProt: Q12887