CD5 Antikörper (Biotin)

Produktnummer ABIN951342

Dieses Anti-CD5-Antikörper ist ein Ratte Monoklonal-Antikörper zur Detektion von CD5 in FACS. Geeignet für Human und Maus.

Kurzübersicht für CD5 Antikörper (Biotin) (ABIN951342)

Target: CD5

Reaktivität: Human, Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser CD5 Antikörper ist konjugiert mit Biotin

Applikation: Flow Cytometry (FACS)

Klon: 03-07-53

Produktdetails anti-CD5 Antikörper (Biotin)

Spezifität: This CD5 (Ly-1) Monoclonal Antibody is specific for the Mouse CD5 antigen.

Aufreinigung: Protein G Chromatography

Immunogen: Mouse thymus or spleen from Balb/c mouse thymus or spleen.

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.1 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative and EIA grade BSA as a stabilizing protein to bring total protein concentration to 4-5 mg/mL

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in alqiuots) -20 °C for longer.

Details zu CD5

Target: CD5

Andere Bezeichnung: CD5

Hintergrund: CD5 is a 55 kDa T lymphocyte single chain transmembrane glycoprotein. It is present on all mature T lymphocytes, on most thymocytes and on many T cell leukemias and lymphomas. It reacts with a subpopulation of activated B cells. CD5/Lyt1 antigen is a monomeric type I transmembrane glycoprotein expressed on thymocytes, T lymphocytes, and a subset of B lymphocytes, but not on natural killer (NK) cells. It has been identified as the major ligand of the B cell antigen CD72. The frequency of CD5+ B cells exhibits strain dependent variation, and the phenotypic, anatomical, functional, developmental, and pathological characteristics of the CD5+ B cells suggest that they may represent a distinct lineage, known as B1 cells. Binding of CD5 on the T cell surface can augment alloantigen or mitogen induced lymphocyte proliferation and induces increased cytosolic free calcium, IL2 secretion, and IL2R expression. It has been proposed that CD5 negatively regulates signal transduction mediated by the T cell and B cell receptors.Synonyms: CD5, LEU1, Lymphocyte antigen T1/Leu-1, T-cell surface glycoprotein CD5

Gen-ID: 12507

NCBI Accession: NP_031676

UniProt: P13379