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CD5 Antikörper (CD5) Primary Antibody

CD5 Reaktivität: Human ELISA, FACS, IHC (fro), IP, WB Wirt: Maus Monoclonal CRIS1 unconjugated
Pubmed (3 references)
Produktnummer ABIN125749
$333.96
Zzgl. Versandkosten $45.00
0.1 mg
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 5 bis 7 Werktagen
  • Target Alle CD5 Antikörper anzeigen
    CD5
    Reaktivität
    • 276
    • 105
    • 87
    • 41
    • 39
    • 27
    • 27
    • 23
    • 21
    • 21
    • 19
    • 15
    • 10
    • 2
    • 2
    • 2
    • 1
    • 1
    Human
    Wirt
    • 242
    • 93
    • 69
    Maus
    Klonalität
    • 328
    • 74
    Monoklonal
    Konjugat
    • 143
    • 47
    • 40
    • 34
    • 23
    • 9
    • 5
    • 5
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CD5 Antikörper ist unkonjugiert
    Applikation
    • 313
    • 113
    • 108
    • 90
    • 89
    • 68
    • 52
    • 38
    • 33
    • 16
    • 13
    • 13
    • 12
    • 6
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    ELISA, Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP), Western Blotting (WB)
    Spezifität
    The antibody CRIS1 reacts with the cell surface glycoprotein CD5, a 67 kDa single-chain transmembrane glycoprotein expressed on mature T lymphocytes, most of thymocytes and B lymphocytes subset (B-1a lymphocytes).
    HLDA I, WS Code T 29
    HLDA III, WS Code T 530
    Kreuzreaktivität (Details)
    Human, Other species Not tested
    Aufreinigung
    Purified by protein-A affinity chromatography
    Reinheit
    > 95 % (by SDS-PAGE)
    Immunogen
    stimulated human leukocytes
    Klon
    CRIS1
    Isotyp
    IgG2a
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Do not freeze.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.
  • Guarné, Bravo, Calvo, Lozano, Vives, Fita: "Conformation of the hypervariable region L3 without the key proline residue." in: Protein science : a publication of the Protein Society, Vol. 5, Issue 1, pp. 167-9, (1996) (PubMed).

    Alberola-Ila, Places, Cantrell, Vives, Lozano: "Intracellular events involved in CD5-induced human T cell activation and proliferation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 148, Issue 5, pp. 1287-93, (1992) (PubMed).

    Arrizabalaga, Mirapeix, Darnell, Torras, Revert: "Cellular immunity analysis using monoclonal antibodies in human glomerulonephritis." in: Nephron, Vol. 53, Issue 1, pp. 41-9, (1989) (PubMed).

  • Target
    CD5
    Andere Bezeichnung
    CD5 (CD5 Produkte)
    Synonyme
    CD5, Ly-1, Ly-12, Ly-A, Lyt-1, LEU1, T1, CD5 molecule, CD5 antigen, CD5 molecule like, Cd5 molecule, CD5, Cd5, CD5L
    Hintergrund
    CD5 antigen (T1, 67 kDa) is a human cell surface T-lymphocyte single-chain transmembrane glycoprotein. CD5 is expressed on all mature T-lymphocytes, most of thymocytes, subset of B-lymphocytes and on many T-cell leukemias and lymphomas. It is a type I membrane glycoprotein whose extracellular region contains three scavenger receptor cysteine-rich (SRCR) domains.The CD5 is a signal transducing molecule whose cytoplasmic tail is devoid of any intrinsic catalytic activity. CD5 modulates signaling through the antigen-specific receptor complex (TCR and BCR). CD5 crosslinking induces extracellular Ca++ mobilization, tyrosine phosphorylation of intracellular proteins and DAG production. Preliminary evidence shows protein associations with ZAP-70, p56lck, p59fyn, PC-PLC, etc. CD5 may serve as a dual receptor, giving either stimulatory or inhibitory signals depending both on the cell type and development stage. In thymocytes and B1a cells seems to provide inhibitory signals, in peripheral mature T lymhocytes it acts as a costimulatory signal receptor. CD5 is the phenotypic marker of a B cell subpopulation involved in the production of autoreactive antibodies.Disease relevance: CD5 is a phenotypic marker for some B cell lymphoproliferative disorders (B-CLL, Hairy cell leukemia, etc.). The CD5+ popuation is expanded in some autoimmune disorders (Rheumatoid Arthritis, etc.). Herpes virus infections induce loss of CD5 expression in the expanded CD8+ human T cells.
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