B-Cell Linker Antikörper (AA 171-356)

Produktnummer ABIN94495

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch B-Cell Linker in WB. Es zeigt Reaktivität gegenüber Proben von Maus.

Kurzübersicht für B-Cell Linker Antikörper (AA 171-356) (ABIN94495)

Target: B-Cell Linker (BLNK)

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser B-Cell Linker Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-B-Cell Linker Antikörper

Bindungsspezifität: AA 171-356

Verwendungszweck: Anti-Ms Blnk Purified

Kreuzreaktivität (Details): Mouse

Produktmerkmale: The polyclonal antibody reacts with mouse SLP65 / BLNK, a cytosolic adaptor protein identified as two phosphoproteins migrating at 68 and 70 kDa in SDS/PAGE (alternatively spliced forms of human SLP65).

Aufreinigung: Purified by protein-A affinity chromatography.

Reinheit: > 95 % (by SDS-PAGE)

Immunogen: A fusion protein representing amino acids 171-356 of human BLNK.

Anwendungsinformationen

Applikationshinweise: Western blotting: Reducing conditions.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Do not freeze

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8°C. Do not freeze.

Details zu B-Cell Linker

Target: B-Cell Linker (BLNK)

Andere Bezeichnung: Blnk

Hintergrund: B cell linkerprovided,SLP65 / BLNK (SH2 domain-containing leukocyte-specific phosphoprotein of 65 kDa, B cell linker protein), also known as BASH, is an adaptor protein that plays key role in B cell activation initiated by cross-linking the B cell receptor (BCR). Phosphorylated by Syk tyrosine kinase, SLP65 serves as a scaffold for Btk tyrosine kinase, Vav1 guanine nucleotide exchange factor, phospholipase C gamma2, as well as Grb2 and Nck adaptor proteins, thus represents a central linker protein that bridges the BCR-associated kinases with a multitude of signaling pathways.,SLP65, BASH, Ly57

Gen-ID: 29760

UniProt: Q8WV28

Pathways: BCR Signaling