SOCS3 Antikörper

Produktnummer ABIN94467

Dieses Anti-SOCS3-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von SOCS3 in WB. Geeignet für Human. Dieses Primary Antibody wurde in 1 Publikation zitiert.

Kurzübersicht für SOCS3 Antikörper (ABIN94467)

Target: SOCS3 (Suppressor of Cytokine Signaling 3 (SOCS3))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SOCS3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: SO1

Produktdetails anti-SOCS3 Antikörper

Verwendungszweck: Anti-SOCS3 Purified

Spezifität: The antibody SO1 reacts with SOCS3, an intracellular cytokine signaling inhibitor.

Kreuzreaktivität (Details): Human

Aufreinigung: Purified by protein-A affinity chromatography.

Reinheit: > 95 % (by SDS-PAGE)

Immunogen: Full-length SOCS3 protein.

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Western blotting: Positive control: HeLa human cervix carcinoma cell line, reducing conditions.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Do not freeze.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8°C. Do not freeze.

Referenzen für anti-SOCS3 Antikörper (ABIN94467)

Neuwirt, Puhr, Cavarretta, Mitterberger, Hobisch, Culig: "Suppressor of cytokine signalling-3 is up-regulated by androgen in prostate cancer cell lines and inhibits androgen-mediated proliferation and secretion." in: Endocrine-related cancer, Vol. 14, Issue 4, pp. 1007-19, (2007) (PubMed).

Details zu SOCS3

Target: SOCS3 (Suppressor of Cytokine Signaling 3 (SOCS3))

Andere Bezeichnung: SOCS3

Hintergrund: Suppressor of cytokine signaling 3,SOCS3 (suppressor of cytokine signaling 3), also known as CIS3 (cytokine-inducible SH2 protein 3) is a negative regulator of particular cytokine signaling pathways. SOCS3 is induced by a variety of cytokines and other stimuli, such as erythropoietin, leptin and lipopolysaccharides and inhibits tyrosinkinase activity of JAK kinases, or e.g. JNK phosphorylation. SOCS3 modulates cytokine-mediated and neoplastic-proliferative responses and is involved also in maintaining leukocytes in quiescent state until antigen stimulation.,SOCS-3, CIS3, SSI3

Gen-ID: 9021

UniProt: Q6FI39

Pathways: JAK-STAT Signalweg, Response to Growth Hormone Stimulus, Hepatitis C