MICA Antikörper

Produktnummer ABIN94335

Produktdetails anti-MICA Antikörper

Target: MICA (MHC Class I Polypeptide-Related Sequence A (MICA))

Reaktivität: Human, Rind (Kuh), Non-Human Primate

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MICA Antikörper ist unkonjugiert

Applikation: ELISA, Flow Cytometry (FACS), Immunoprecipitation (IP)

Spezifität: The antibody MEM-123 reacts with an extracellular epitope of all human classical MHC Class I molecules (major histocompatibility complex) in native cell-surface forms as well as with human HLA-G cDNA transfected cells. MHC Class I molecules (MHC Class Ia) are expressed on the surface of all human cell types. The antibody MEM-123 completely blocks binding of classical W6/32 to surface-expressed HLA-G, but does not cross-blocks the antibody MEM-G/9.

Kreuzreaktivität (Details): Human, Non-Human Primates, Bovine

Aufreinigung: Purified by protein-A affinity chromatography.

Reinheit: > 95 % (by SDS-PAGE)

Immunogen: COS-7 African green monkey kidney cells

Klon: MEM-123

Isotyp: IgG3

Anwendungsinformationen

Applikationshinweise: Flow cytometry: Recommended dilution: 4 μg/mL.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Do not freeze.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8°C. Do not freeze.

Details zu MICA

Target: MICA (MHC Class I Polypeptide-Related Sequence A (MICA))

Andere Bezeichnung: HLA-Class I (MICA Produkte)

Synonyme: MIC-A antikoerper, PERB11.1 antikoerper, MHC class I polypeptide-related sequence A antikoerper, MICA antikoerper

Hintergrund: HLA-class I major histocompatibility (MHC) antigens are intrinsic membrane glycoproteins expressed on nucleated cells and noncovalently associated with an invariant beta2 microglobulin. They carry foreign determinants important for immune recognition by cytotoxic T cells, thus important for anti-viral and anti-tumour defence. Human HLA-class I antigens are represented by HLA-A, HLA-B and HLA-C molecules.

Pathways: Activation of Innate immune Response, Transition Metal Ion Homeostasis