Clusterin Antikörper (CLU)

Details for Product anti-CLU Antibody No. ABIN94264, Anbieter: Anmelden zum Anzeigen
Antigen
  • LOC100136120
  • clu
  • MGC53055
  • zgc:73352
  • xclu
  • MGC89163
  • CLU
  • APO-J
  • APOJ
  • CLI
  • CLU1
  • CLU2
  • KUB1
  • NA1/NA2
  • SGP-2
  • SGP2
  • SP-40
  • TRPM-2
  • TRPM2
  • DAG
  • RATTRPM2B
  • SP40
  • TRPM2B
  • Trpm2
  • Trpmb
  • AI893575
  • ApoJ
  • Cli
  • D14Ucla3
  • Sgp-2
  • Sgp2
  • Sugp-2
  • GP80
  • gpIII
  • 40
  • clusterin-1
  • clusterin L homeolog
  • clusterin
  • Clusterin
  • LOC100136120
  • clu.L
  • clu
  • CLU
  • clus
  • Clu
  • LOC101113728
Reaktivität
Human
304
60
57
18
17
5
3
3
3
2
1
1
1
Wirt
Maus
172
138
77
8
5
2
Klonalität (Klon)
Monoklonal ()
Konjugat
Dieser Clusterin Antikörper ist unkonjugiert
33
27
12
12
11
7
4
3
3
3
3
3
3
3
3
3
2
1
1
Applikation
Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA, Western Blotting (WB)
360
276
158
105
60
53
32
29
23
15
13
7
2
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen Freshly ejaculated human sperms were washed in PBS and extracted in 3% acetic acid, 10% glycerol, 30 mM benzaminidine. The acid extract was dialyzed against 0.2% acetic acid and subsequently used for immunization.
Klon Hs-3
Isotyp IgG1
Keine Kreuzreaktivität Schwein, Rind (Kuh), Hund, Katze
Reinigung Purified from ascites by protein-A affinity chromatography.
Reinheit > 95 % (by SDS-PAGE)
Andere Bezeichnung CLU (CLU Antibody Abstract)
Hintergrund Clusterin (APO J, SGP-2, TRPM-2, SP-40, pADHC-9, CLJ, T64, GP III, XIP8) is a 75-80 kD disulfide-linked heterodimeric protein containing about 30 % of N-linked carbohydrate rich in sialic acid but truncated forms targeted to the nucleus have also been identified. It is a conserved secreted glycoprotein expressed by a wide range of tissues and being implicated in many physiological processes, including e.g. lipid transportation, complement inhibition, tissue remodeling, membrane recycling, or clearence of cellular debris. It is nearly ubiqitously expressed in most mammalian tissues and can be found in plasma, milk, urine, cerebrospinal fluid and semen. Clusterin is able to bind and form complexes with numerous partners (immunoglobulins, lipids, heparin, bacteria, complement components, paraoxonase, beta amyloid, leptin etc.) and is expressed in many pathological and clinically relevant situations including cancer, organ regeneration, infection, Alzheimer disease, retinitis pigmentosa, myocardial infarction, renal tubular damage, autoimmunity and others. A genuine function of clusterin is still enigmatic.
Pathways Apoptose, Negative Regulation of intrinsic apoptotic Signaling
Applikations-hinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1 mg/mL
Buffer Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Do not freeze.
Lagerung 4 °C
Informationen zur Lagerung Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.
Allgemeine Veröffentlichungen Pérez-Rubio, Eiros Bouza, Castrodeza Sanz: "[Evaluation of the influenza a H1N1 vaccination in Castilla and Leon regions, Spain]." in: Medicina clínica, Vol. 135, Issue 12, pp. 543-5, 2010 (PubMed).

Schepeler, Mansilla, Christensen, Orntoft, Andersen: "Clusterin expression can be modulated by changes in TCF1-mediated Wnt signaling." in: Journal of molecular signaling, Vol. 2, pp. 6, 2007 (PubMed).

Cochrane, Wang, Muramaki, Gleave, Nelson: "Differential regulation of clusterin and its isoforms by androgens in prostate cells." in: The Journal of biological chemistry, Vol. 282, Issue 4, pp. 2278-87, 2007 (PubMed).

Shannan, Seifert, Boothman, Tilgen, Reichrath: "Clusterin and DNA repair: a new function in cancer for a key player in apoptosis and cell cycle control." in: Journal of molecular histology, Vol. 37, Issue 5-7, pp. 183-8, 2006 (PubMed).

Pajak, Orzechowski: "Clusterin: the missing link in the calcium-dependent resistance of cancer cells to apoptogenic stimuli." in: Postȩpy higieny i medycyny doświadczalnej (Online), Vol. 60, pp. 45-51, 2006 (PubMed).

Produkt verwendet in: Capková, Geussová, Peknicová: "New monoclonal antibody to human apolipoprotein J." in: Folia biologica, Vol. 48, Issue 1, pp. 40-2, 2002 (PubMed).

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