Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

CD80 Antikörper (Extracellular Domain)

This anti-CD80 antibody (ABIN94239) is a Mouse Monoclonal antibody detecting CD80 in FACS, IP. Suitable for Human.
Produktnummer ABIN94239

Quick Overview for CD80 Antikörper (Extracellular Domain) (ABIN94239)

Target

Alle CD80 Antikörper anzeigen
CD80

Reaktivität

  • 157
  • 110
  • 46
  • 8
  • 6
  • 6
  • 1
  • 1
  • 1
Human

Wirt

  • 98
  • 80
  • 22
  • 21
  • 18
  • 2
  • 1
Maus

Klonalität

  • 158
  • 81
  • 2
Monoklonal

Konjugat

  • 99
  • 22
  • 19
  • 16
  • 12
  • 5
  • 4
  • 4
  • 4
  • 4
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser CD80 Antikörper ist unkonjugiert

Applikation

  • 143
  • 96
  • 74
  • 40
  • 38
  • 26
  • 14
  • 13
  • 13
  • 13
  • 11
  • 10
  • 9
  • 6
  • 5
  • 4
  • 3
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Flow Cytometry (FACS), Immunoprecipitation (IP)

Klon

MEM-233
  • Bindungsspezifität

    • 16
    • 15
    • 11
    • 8
    • 7
    • 6
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Extracellular Domain

    Verwendungszweck

    Anti-Hu CD80 Purified

    Spezifität

    The antibody MEM-233 reacts with an extracellular epitope of CD80 (B7-1), a 60 kDa single chain type I glycoprotein of immunoglobulin supergene family, expressed on professional antigen-presenting cells, such as dendritic cells, macrophages or activated B lymphocytes.

    Kreuzreaktivität (Details)

    Human

    Aufreinigung

    Purified by protein-A affinity chromatography.

    Reinheit

    > 95 % (by SDS-PAGE)

    Immunogen

    Extracellular domain of human CD80 fused to human IgG1(Fc)

    Isotyp

    IgG1
  • Applikationshinweise

    Flow cytometry: Recommended dilution: 1-4 μg/mL.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Konzentration

    1 mg/mL

    Buffer

    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Do not freeze.

    Lagerung

    4 °C

    Informationen zur Lagerung

    Store at 2-8°C. Do not freeze.
  • Silk, Leishman, Nishimoto, Reddy, Fairchild: "Rapamycin conditioning of dendritic cells differentiated from human ES cells promotes a tolerogenic phenotype." in: Journal of biomedicine & biotechnology, Vol. 2012, pp. 172420, (2012) (PubMed).

    Hovden, Karlsen, Jonsson, Aarstad, Appel: "Maturation of monocyte derived dendritic cells with OK432 boosts IL-12p70 secretion and conveys strong T-cell responses." in: BMC immunology, Vol. 12, pp. 2, (2011) (PubMed).

    Lee, Sieling, Ochoa, Krutzik, Guo, Hernandez, Rea, Cheng, Colonna, Modlin: "LILRA2 activation inhibits dendritic cell differentiation and antigen presentation to T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 179, Issue 12, pp. 8128-36, (2007) (PubMed).

    Kolar, Mehta, Pelayo, Capra: "A novel human B cell subpopulation representing the initial germinal center population to express AID." in: Blood, Vol. 109, Issue 6, pp. 2545-52, (2007) (PubMed).

    Campioni, Moretti, Ferrari, Punturieri, Castoldi, Lanza: "Immunophenotypic heterogeneity of bone marrow-derived mesenchymal stromal cells from patients with hematologic disorders: correlation with bone marrow microenvironment." in: Haematologica, Vol. 91, Issue 3, pp. 364-8, (2006) (PubMed).

    Tan, Beutelspacher, Wang, McClure, Ritter, Lombardi, George: "Immunolipoplexes: an efficient, nonviral alternative for transfection of human dendritic cells with potential for clinical vaccination." in: Molecular therapy : the journal of the American Society of Gene Therapy, Vol. 11, Issue 5, pp. 790-800, (2005) (PubMed).

    Zhan, Towler, Calder: "The immunomodulatory role of human conjunctival epithelial cells." in: Investigative ophthalmology & visual science, Vol. 44, Issue 9, pp. 3906-10, (2003) (PubMed).

  • Target

    CD80

    Andere Bezeichnung

    CD80

    Hintergrund

    CD80 Molecule,CD80 (B7-1) and CD86 (B7-2) are ligands of T cell critical costimulatory molecule CD28 and of an inhibitory receptor CTLA-4 (CD152). The both B7 Molecules are expressed on professional antigen-presenting cells and are essential for T cell activation, the both molecules can also substitute for each other in this process. The question what are the differences in CD80 and CD86 competency has not been fully elucidated yet, there are still conflicts in results about their respective roles in initiation or sustaining of the T cell immune response.,B7-1, BB1

    Gen-ID

    941

    UniProt

    P33681

    Pathways

    T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints
Sie sind hier:
Chat with us!