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CD72 Antikörper

CD72 Reaktivität: Human FACS, IP Wirt: Maus Monoclonal 3F3 unconjugated
Produktnummer ABIN94227
  • Target Alle CD72 Antikörper anzeigen
    CD72 (CD72 Molecule (CD72))
    Reaktivität
    • 46
    • 19
    • 1
    Human
    Wirt
    • 37
    • 20
    • 1
    Maus
    Klonalität
    • 37
    • 21
    Monoklonal
    Konjugat
    • 25
    • 8
    • 7
    • 6
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CD72 Antikörper ist unkonjugiert
    Applikation
    • 29
    • 24
    • 22
    • 8
    • 6
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Immunoprecipitation (IP)
    Spezifität
    The mouse monoclonal antibody 3F3 recognizes an extracellular epitope of CD72, a 39-43 kDa type II membrane glycoprotein (C-type lectin family). CD72 is a pan-B cell marker expressed throughout the B lymphocytes diferentiation with the exception of plasma cells, it is also present on follicular dendritic cells.
    Kreuzreaktivität (Details)
    Human
    Aufreinigung
    Purified by protein-A affinity chromatography.
    Reinheit
    > 95 % (by SDS-PAGE)
    Immunogen
    Normal human lymphocytes from a lymph node.
    Klon
    3F3
    Isotyp
    IgG2b
  • Applikationshinweise
    Flow cytometry: Recommended dilution: 1 μg/mL.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Konservierungsmittel
    Sodium azide
    Handhabung
    Do not freeze.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store at 2-8°C. Do not freeze.
  • Mizrahi, Markel, Porgador, Bushkin, Mandelboim: "CD100 on NK cells enhance IFNgamma secretion and killing of target cells expressing CD72." in: PLoS ONE, Vol. 2, Issue 9, pp. e818, (2007) (PubMed).

  • Target
    CD72 (CD72 Molecule (CD72))
    Andere Bezeichnung
    CD72 (CD72 Produkte)
    Synonyme
    CD72c antikoerper, Ly-19 antikoerper, Ly-32 antikoerper, Ly-m19 antikoerper, Lyb-2 antikoerper, CD72b antikoerper, LYB2 antikoerper, CD72 antigen antikoerper, CD72 molecule antikoerper, Cd72 antikoerper, CD72 antikoerper
    Hintergrund
    CD72 Molecule,CD72 is a transmembrane glycoprotein expressed as a homodimer especially in B cells, but also in other antigen presenting cells such as dendritic cells and macrophages. Through one of its immunoreceptor tyrosine-based inhibitory motives (ITIMs), CD72 interacts with tyrosine phosphatase SHP-1, thereby suppressing B cell responsiveness. Binding of CD72 with its ligand CD100 (Sema4D) prevents BCR association and phosphorylation of CD72 and results in dissociation of SHP-1 from CD72, thus enables B cell activation.,LYB2
    Gen-ID
    971
    UniProt
    P21854
    Pathways
    BCR Signaling
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