CD59 Antikörper
Kurzübersicht für CD59 Antikörper (ABIN94204)
Target
Alle CD59 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
Klon
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Verwendungszweck
- Anti-Hu CD59 Purified Azide Free
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Spezifität
- The antibody MEM-129 reacts with CD59 (Protectin), a 18-20 kDa glycosylphosphatidylinositol (GPI)-anchored extracellular glycoprotein expressed on all hematopoietic cells, it is widely present on cells in all tissus.
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Kreuzreaktivität (Details)
- Human, Porcine
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Aufreinigung
- Purified by sequential steps of physicochemical fractionation (differential precipitation and solid-phase chromatography methods).
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Reinheit
- > 95 % (by SDS-PAGE)
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Immunogen
- Human peripheral blood lymphocytes
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Isotyp
- IgM
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Applikationshinweise
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Functional application: The antibody MEM-129 activates T cells.
Flow cytometry: Recommended dilution: 1-4 μg/mL. -
Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Konzentration
- 1 mg/mL
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Buffer
- Tris buffered saline (TBS), pH 8.0
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Konservierungsmittel
- Azide free
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Handhabung
- Do not freeze.
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Lagerung
- 4 °C
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Informationen zur Lagerung
- Store at 2-8°C. Do not freeze.
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Signal transduction via glycosyl phosphatidylinositol-anchored proteins in T cells is inhibited by lowering cellular cholesterol." in: The Journal of biological chemistry, Vol. 272, Issue 31, pp. 19242-7, (1997) (PubMed).
: "CD64/Fc gamma RI is a granulo-monocytic lineage marker on CD34+ hematopoietic progenitor cells." in: Blood, Vol. 85, Issue 9, pp. 2402-13, (1995) (PubMed).
: "
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Signal transduction via glycosyl phosphatidylinositol-anchored proteins in T cells is inhibited by lowering cellular cholesterol." in: The Journal of biological chemistry, Vol. 272, Issue 31, pp. 19242-7, (1997) (PubMed).
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- CD59
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Andere Bezeichnung
- CD59
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Hintergrund
- CD59 Molecule,CD59 (protectin) is a small (18-20 kDa) GPI-anchored ubiquitously expressed inhibitor of the membrane attack complex (MAC). It is thus the key regulator that preserves the autologous cells from terminal effector mechanism of the complement cascade. CD59 associates with C5b-8 complex and thereby counteracts appropriate formation of cytolytic pore within the plasma membrane. CD59 is also an low-affinity ligand of human CD2 and causes T cell costimulation.,MACIF, MAC-IP, protectin, MIRL, HRF-20, HRF20, 1F5, MIN
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Gen-ID
- 966
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UniProt
- P13987
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Pathways
- Komplementsystem
Target
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