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CD59 Antikörper (FITC)

Dieses Maus Monoklonal-Antikörper erkennt spezifisch CD59 in FACS. Er zeigt eine Reaktivität gegenüber Human und wurde in 5+ Publikationen erwähnt.
Produktnummer ABIN94201

Kurzübersicht für CD59 Antikörper (FITC) (ABIN94201)

Target

Alle CD59 Antikörper anzeigen
CD59

Reaktivität

  • 159
  • 17
  • 13
  • 11
  • 5
  • 5
  • 5
  • 1
  • 1
Human

Wirt

  • 97
  • 93
  • 8
  • 6
Maus

Klonalität

  • 106
  • 95
  • 1
Monoklonal

Konjugat

  • 106
  • 25
  • 13
  • 13
  • 8
  • 4
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser CD59 Antikörper ist konjugiert mit FITC

Applikation

  • 106
  • 96
  • 75
  • 47
  • 47
  • 41
  • 33
  • 24
  • 16
  • 14
  • 13
  • 13
  • 11
  • 11
  • 8
  • 3
  • 3
  • 3
  • 1
  • 1
  • 1
Flow Cytometry (FACS)

Klon

MEM-43
  • Verwendungszweck

    Anti-Hu CD59 FITC

    Spezifität

    The antibody MEM-43 reacts with well defined epitope (W40, R-53) on CD59 (Protectin), an 18-20 kDa glycosylphosphatidylinositol (GPI)-anchored glycoprotein expressed on the surface of all hematopoietic cells, it is widely present on cells in all tissues. This antibody does not compete with MEM-43/5, and has blocking activity.

    Kreuzreaktivität (Details)

    Human

    Aufreinigung

    Purified antibody is conjugated with fluorescein isothiocyanate (FITC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

    Immunogen

    Thymocytes and T lymphocytes

    Isotyp

    IgG2a kappa
  • Applikationshinweise

    Flow cytometry: The reagent is designed for analysis of human blood cells using 20 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (2 ml) is sufficient for 100 tests.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Rekonstitution

    No reconstitution is necessary.

    Buffer

    Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Do not freeze.
    Avoid prolonged exposure to light.

    Lagerung

    4 °C

    Informationen zur Lagerung

    Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
  • Omidvar, Wang, Brennan, Longhi, Smith, Morgan: "Expression of glycosylphosphatidylinositol-anchored CD59 on target cells enhances human NK cell-mediated cytotoxicity." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 176, Issue 5, pp. 2915-23, (2006) (PubMed).

    Ilangumaran, Briol, Hoessli: "CD44 selectively associates with active Src family protein tyrosine kinases Lck and Fyn in glycosphingolipid-rich plasma membrane domains of human peripheral blood lymphocytes." in: Blood, Vol. 91, Issue 10, pp. 3901-8, (1998) (PubMed).

    Stefanová, Horejsí, Ansotegui, Knapp, Stockinger: "GPI-anchored cell-surface molecules complexed to protein tyrosine kinases." in: Science (New York, N.Y.), Vol. 254, Issue 5034, pp. 1016-9, (1991) (PubMed).

    Forsberg, Bazil, Stefanová, Schröder: "Gene for human CD59 (likely Ly-6 homologue) is located on the short arm of chromosome 11." in: Immunogenetics, Vol. 30, Issue 3, pp. 188-93, (1989) (PubMed).

    Stefanová, Hilgert, Kristofová, Brown, Low, Horejsí: "Characterization of a broadly expressed human leucocyte surface antigen MEM-43 anchored in membrane through phosphatidylinositol." in: Molecular immunology, Vol. 26, Issue 2, pp. 153-61, (1989) (PubMed).

  • Target

    CD59

    Andere Bezeichnung

    CD59

    Hintergrund

    CD59 Molecule,CD59 (protectin) is a small (18-20 kDa) GPI-anchored ubiquitously expressed inhibitor of the membrane attack complex (MAC). It is thus the key regulator that preserves the autologous cells from terminal effector mechanism of the complement cascade. CD59 associates with C5b-8 complex and thereby counteracts appropriate formation of cytolytic pore within the plasma membrane. CD59 is also an low-affinity ligand of human CD2 and causes T cell costimulation.,MACIF, MAC-IP, protectin, MIRL, HRF-20, HRF20, 1F5, MIN

    Gen-ID

    966

    UniProt

    P13987

    Pathways

    Komplementsystem
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