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CD47 Antikörper

This anti-CD47 antibody (ABIN94154) is a Mouse Monoclonal antibody detecting CD47 in FACS, WB, IHC (fro). Suitable for Human, Pig, Non-Human Primate.
Produktnummer ABIN94154

Kurzübersicht für CD47 Antikörper (ABIN94154)

Target

Alle CD47 Antikörper anzeigen
CD47

Reaktivität

  • 132
  • 53
  • 26
  • 6
  • 3
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
Human, Schwein, Non-Human Primate

Wirt

  • 79
  • 70
  • 9
  • 4
  • 1
Maus

Klonalität

  • 89
  • 69
  • 4
Monoklonal

Konjugat

  • 77
  • 13
  • 11
  • 7
  • 4
  • 4
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser CD47 Antikörper ist unkonjugiert

Applikation

  • 101
  • 84
  • 46
  • 44
  • 40
  • 26
  • 26
  • 19
  • 18
  • 15
  • 12
  • 12
  • 9
  • 6
  • 5
  • 4
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Flow Cytometry (FACS), Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))

Klon

MEM-122
  • Verwendungszweck

    Anti-Hu CD47 Purified

    Spezifität

    The antibody MEM-122 reacts with an extracellular epitope of CD47 (Integrin Associated Protein), a 50-55 kDa membrane adhesion molecule (thrombospondin receptor, immunoglobulin supergene family) expressed on leukocytes, platelets and erythrocytes. It is also expressed on epithelial cells, endothelial cells, fibroblasts and many tumor cell lines.

    Kreuzreaktivität (Details)

    Non-Human Primates, Human, Porcine

    Aufreinigung

    Purified by sequential steps of physicochemical fractionation (differential precipitation and solid-phase chromatography methods).

    Reinheit

    > 95 % (by SDS-PAGE)

    Immunogen

    COS-7 (African green monkey) cells

    Isotyp

    IgM
  • Applikationshinweise

    Flow cytometry: Recommended dilution: 1-4 μg/mL.
    Western blotting: Non-reducing conditions.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Konzentration

    1 mg/mL

    Buffer

    Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Do not freeze.

    Lagerung

    4 °C

    Informationen zur Lagerung

    Store at 2-8°C. Do not freeze.
  • Smith, Patel, Seatter, Deehan, Brown, Brooke, Goodridge, Howard, Rigley, Harnett, Harnett: "A novel MyD-1 (SIRP-1alpha) signaling pathway that inhibits LPS-induced TNFalpha production by monocytes." in: Blood, Vol. 102, Issue 7, pp. 2532-40, (2003) (PubMed).

  • Target

    CD47

    Andere Bezeichnung

    CD47

    Hintergrund

    CD47 Molecule,CD47 (integrin-associated protein, IAP) is an ubiquitously expressed cell surface transmembrane glycoprotein interacting with several integrins and regulating their functions. Engagement of CD47 by soluble ligands or counter receptors modulates various signaling pathways, such as activation of heterotrimeric G proteins. Binding secreted thrombospondin-1, CD47 counteracts graft vascularization. CD47 acts also as a ligand for CD172a (signal regulatory protein alpha, SIRP alpha), an immune inhibitory receptor on macrophages, this interaction prevents phagocytosis of CD47-positive cells. Moreover, CD47-CD172a system affects cell migration, B cell adhesion and T cell activation. CD47 is also involved in modulation of chondrocyte responses to mechanical signals, and promotes neuronal development, being especially abundant in synapse-rich regions of brain and retina.,IAP, OA3, MER6

    Gen-ID

    961

    UniProt

    Q08722
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