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CD45RA Antikörper (FITC)

This anti-CD45RA antibody (ABIN94138) is a Mouse Monoclonal antibody detecting CD45RA in FACS. Suitable for Human.
Produktnummer ABIN94138

Quick Overview for CD45RA Antikörper (FITC) (ABIN94138)

Target

Alle CD45RA Antikörper anzeigen
CD45RA

Reaktivität

  • 100
  • 9
  • 6
  • 5
  • 2
  • 2
  • 2
  • 1
  • 1
Human

Wirt

  • 116
  • 1
  • 1
Maus

Klonalität

  • 117
  • 1
Monoklonal

Konjugat

  • 31
  • 16
  • 14
  • 7
  • 6
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser CD45RA Antikörper ist konjugiert mit FITC

Applikation

  • 110
  • 28
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  • 26
  • 19
  • 18
  • 15
  • 15
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
Flow Cytometry (FACS)

Klon

MEM-56
  • Verwendungszweck

    Anti-Hu CD45RA FITC

    Spezifität

    The antibody MEM-56 reacts with an extracellular epitope of CD45RA, a 205-220 kDa single chain type I glycoprotein, variant of CD45 (CD45RA isoform). CD45RA is expressed on most of B lymphocytes, resting and native T lymphocytes, medullar thymocytes and monocytes.

    Kreuzreaktivität (Details)

    Human

    Aufreinigung

    Purified antibody is conjugated with fluorescein isothiocyanate (FITC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

    Immunogen

    Human thymocytes and T lymphocytes.

    Isotyp

    IgG2b
  • Applikationshinweise

    Flow cytometry: The reagent is designed for analysis of human blood cells using 20 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (2 ml) is sufficient for 100 tests.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Rekonstitution

    No reconstitution is necessary.

    Buffer

    Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Do not freeze.
    Avoid prolonged exposure to light.

    Lagerung

    4 °C

    Informationen zur Lagerung

    Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
  • Bazil, Stefanová, Hilgert, Kristofová, Van?k, Bukovský, Horejsí: "Monoclonal antibodies against human leucocyte antigens. III. Antibodies against CD45R, CD6, CD44 and two newly described broadly expressed glycoproteins MEM-53 and MEM-102." in: Folia biologica, Vol. 35, Issue 5, pp. 289-97, (1990) (PubMed).

  • Target

    CD45RA

    Andere Bezeichnung

    CD45RA

    Hintergrund

    CD45RA is a high molecular weight isoform of a receptor-type protein tyrosine phosphatase, CD45 glycoprotein. CD45 is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45 isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45RA is expressed e.g. on naïve T cells and normal plasma cells.,PTPRCR, T200RA
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