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CD38 Antikörper

Dieses Anti-CD38-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von CD38 in FACS, IHC (fro) und IHC (p). Geeignet für Human. Dieses Primary Antibody wurde in 3+ Publikationen zitiert.
Produktnummer ABIN94083

Kurzübersicht für CD38 Antikörper (ABIN94083)

Target

Alle CD38 Antikörper anzeigen
CD38

Reaktivität

  • 202
  • 74
  • 29
  • 12
  • 12
  • 12
  • 2
  • 1
  • 1
Human

Wirt

  • 129
  • 110
  • 34
  • 1
  • 1
  • 1
  • 1
Maus

Klonalität

  • 191
  • 84
  • 1
Monoklonal

Konjugat

  • 107
  • 17
  • 16
  • 13
  • 12
  • 6
  • 6
  • 5
  • 5
  • 4
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser CD38 Antikörper ist unkonjugiert

Applikation

  • 178
  • 90
  • 74
  • 47
  • 43
  • 38
  • 30
  • 26
  • 26
  • 16
  • 13
  • 6
  • 3
  • 3
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon

HIT2
  • Verwendungszweck

    Anti-Hu CD38 Purified

    Spezifität

    The mouse monoclonal antibody HIT2 reacts with an extracellular epitope of CD38, a 45 kDa type II transmembrane glycoprotein strongly expressed mainly on plasma cells and activated T and B lymphocytes, it is an antigenic marker of lymphoid cells. Its binding is blocked by daratumumab.

    Kreuzreaktivität (Details)

    Human

    Aufreinigung

    Purified by protein-A affinity chromatography.

    Reinheit

    > 95 % (by SDS-PAGE)

    Immunogen

    Human thymocytes in foetus

    Isotyp

    IgG1
  • Applikationshinweise

    Immunohistochemistry (paraffin sections): Recommended dilution: 10 μg/mL.
    Flow cytometry: Recommended dilution: 1-4 μg/mL

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Konzentration

    1 mg/mL

    Buffer

    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Do not freeze.

    Lagerung

    4 °C

    Informationen zur Lagerung

    Store at 2-8°C. Do not freeze.
  • Všianská, Říhová, Varmužová, Suská, Kryukov, Mikulášová, Kupská, Penka, Pour, Adam, Hájek: "Analysis of B-cell subpopulations in monoclonal gammopathies." in: Clinical lymphoma, myeloma & leukemia, Vol. 15, Issue 4, pp. e61-71, (2015) (PubMed).

    Rozková, Novotná, Pytlík, Hochová, Kozák, Bart?nková, Spísek: "Toll-like receptors on B-CLL cells: expression and functional consequences of their stimulation." in: International journal of cancer. Journal international du cancer, Vol. 126, Issue 5, pp. 1132-43, (2010) (PubMed).

    Kolar, Mehta, Pelayo, Capra: "A novel human B cell subpopulation representing the initial germinal center population to express AID." in: Blood, Vol. 109, Issue 6, pp. 2545-52, (2007) (PubMed).

  • Target

    CD38

    Hintergrund

    CD38 Molecule,CD38 (NAD+ glycohydrolase) is a type II transmembrane glycoprotein able to induce activation, proliferation and differentiation of mature lymphocytes and mediate apoptosis of myeloid and lymphoid progenitor cells. Another role of CD38 is provided by enzymatic activity of its extracellular part. CD38 acts as NAD+ glycohydrolase converting NAD+ into ADP-ribose, as ADP-ribosyl cyclase producing cADPR and as cADPR hydrolase, thus affecting levels of calcium-mobilizing metabolites. ADPR produced by CD38 serves as an important second messenger of neutrophil and dendritic cell migration.,ADPRC1, cADPr hydrolase 1, T10, NAD(+) nucleosidase, ADP-ribosyl cyclase 1

    Gen-ID

    952

    UniProt

    P28907
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